Cybb - cytochrome b-245 beta chain Gene

中文名称：细胞色素 b-245 β 链

种属: Rattus norvegicus

同用名: Nox2; Gp91-phox

关于 Cybb

功能概要

预计该基因编码的蛋白具有多种功能，包括黄素腺嘌呤二核苷酸结合活性；血红素结合活性；和蛋白质异二聚化活性。预计有助于电子转移活动。参与多个过程，包括细胞对 L-谷氨酰胺的反应；缺氧诱导因子 1alpha 信号通路；和肿瘤坏死因子产生的正调节。位于几种细胞成分中，包括神经细胞体；核包膜；和粗面内质网。 NADPH 氧化酶复合物的一部分。与核周内质网共定位。动脉疾病的生物标志物（多种）；晚期肾脏疾病;原发性醛固酮增多症;和肾纤维化。该基因的人类直系同源基因与 X 连锁慢性肉芽肿病有关；慢性肉芽肿病；和免疫缺陷 34. 与人类 CYBB（细胞色素 b-245 β 链）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including flavin adenine dinucleotide binding activity; heme binding activity; and protein heterodimerization activity. Predicted to contribute to electron transfer activity. Involved in several processes, including cellular response to L-glutamine; hypoxia-inducible factor-1alpha signaling pathway; and positive regulation of tumor necrosis factor production. Located in several cellular components, including neuronal cell body; nuclear envelope; and rough endoplasmic reticulum. Part of NADPH Oxidase complex. Colocalizes with perinuclear endoplasmic reticulum. Biomarker of artery disease (multiple); end stage renal disease; primary hyperaldosteronism; and renal fibrosis. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain). [provided by Alliance of Genome Resources, Apr 2022]