1. Gene
  2. SOD3 - superoxide dismutase 3 Gene

SOD3 - superoxide dismutase 3 Gene

中文名称:超氧化物歧化酶 3

种属: Homo sapiens

同用名: EC-SOD

基因 ID: 6649 | 基因类型: protein coding

关于 SOD3

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:24,795,573-24,800,842 (from NCBI)

This gene has 3 transcripts (splice variants), 190 orthologues and 2 paralogues. Broad expression in fat (RPKM 92.3), kidney (RPKM 26.6) and 19 other tissues.

功能概要

该基因编码超氧化物歧化酶 (SOD) 蛋白家族的成员。 SOD 是一种抗氧化酶,可催化超氧自由基转化为过氧化氢和氧气,从而保护大脑、肺和其他组织免受氧化应激。编码蛋白的蛋白水解加工导致形成两种不同的同源四聚体,它们与细胞外基质 (ECM) 相互作用的能力不同。由完整蛋白质或 C 型亚基组成的同源四聚体对肝素表现出高亲和力,并锚定在 ECM 上。由蛋白水解切割形式或 A 型亚基组成的同源四聚体对肝素表现出低亲和力,并且不与 ECM 相互作用。该基因的突变可能与心脏病风险增加有关。[RefSeq 提供,2015 年 10 月]

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant Enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and Other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

SOD3 基因产物(1)

mRNA Protein Name
NM_003102.4 NP_003093.2 extracellular superoxide dismutase [Cu-Zn] preproprotein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity EXP
EXP: 通过实验结果推断
19289127 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15528465 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
9699963 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SOD3 蛋白结构

Sod_Cu

Sod_Cu: Copper/zinc superoxide dismutase (SODC) (69 - 210)

  • 0
  • 100
  • 200
  • 240 a.a.
蛋白主名 其他名称

extracellular superoxide dismutase [Cu-Zn]

superoxide dismutase 3, extracellular

SOD3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SOD3 P08294 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
种属内
SOD3 P08294 KCNIP1 Homo sapiens Q9NZI2-2
Validated Y2H
32296183
种属内
SOD3 P08294 KCNIP1 Homo sapiens Q9NZI2-2
Y2H Array
32296183
种属内
SOD3 P08294 KCNIP1 Homo sapiens Q9NZI2-2
Y2H Prey Pooling
32296183
种属内
SOD3 P08294 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
种属内
SOD3 P08294 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
SOD3 P08294 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
种属内
SOD3 P08294 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
种属内
SOD3 P08294 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
SOD3 P08294 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
SOD3 P08294 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
SOD3 P08294 KCNIP3 Homo sapiens Q9Y2W7
Y2H Prey Pooling
32296183
种属内
SOD3 P08294 KCNIP3 Homo sapiens Q9Y2W7
Validated Y2H
32296183
种属内
SOD3 P08294 KCNIP3 Homo sapiens Q9Y2W7
Y2H Array
32296183
种属内
SOD3 P08294 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
SOD3 P08294 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
SOD3 P08294 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

SOD3 抗体

目录号 产品名 应用 反应物种
HY-P82675 Superoxide Dismutase 3 Antibody (YA2420) WB, IHC-P Human

关联疾病

疾病名称 别名
Asbestosis

Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

Pulmonary Fibrosis - From Asbestos Exposure

Myocardial Stunning
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Diabetic Neuropathy

Diabetic Neuropathies

Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea

Pulmonary Fibrosis

Fibrosis Of Lung

Bullous Keratopathy

Bk - [Bullous Keratopathy]

Homocystinuria

Cystathionine Beta Synthase Deficiency

Homocysteinemia

Cbs Deficiency

Cystathionine Synthase Deficiency

Cystathionine Beta-Synthase Deficiency Disease

Acatalasemia

Acatalasia

Catalase Deficiency

Deficiency Of Catalase

ACATLAS

Takahara'S Disease

Takahara Disease

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease

COPD

Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

Chronic Obstructive Lung Disease

Chronic Obstructive Airway Disease

Pulmonary Disease, Chronic Obstructive, Susceptibility To

Cold

Severe Early-Onset Chronic Obstructive Pulmonary Disease

Pulmonary Disease Chronic Obstructive

Pulmonary Disease, Obstructive, Chronic, Susceptibility To

Chronic Obstructive Pulmonary Disease Of Horses

Common Cold

Upper Respiratory Infections

Copd - [Chronic Obstructive Pulmonary Disease]

Coad - [Chronic Obstructive Airways Disease]

Cold - [Chronic Obstructive Lung Disease]

Chronic Airway Disease Nos

Chronic Airways Limitation, Unspecified

Chronic Obstructed Airway, Unspecified

Chronic Obstructive Airway Disease, Unspecified

Chronic Obstructive Airway, Unspecified

Obstructive Lung Disease Nos

Chronic Obstructive Lung Disease Nos

Chronic Obstructive Lung Nos

Obstructive Pulmonary Disease Nos

Exacerbation Copd Nos

Acute Exacerbation Copd

Complement Component 7 Deficiency

C7 Deficiency

C7D

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities

Diabetes Mellitus

Diabetes

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SOD3 VGNC VGNC:107467
Mus musculus SOD3 MGD MGI:103181
Canis familiaris SOD3 VGNC VGNC:46654
Macaca mulatta SOD3 VGNC VGNC:77688
Bos taurus SOD3 VGNC VGNC:35126
Rattus norvegicus SOD3 RGD RGD:3733
Others SOD3 NCBI