2. Gene
  3. BOK - BCL2 family apoptosis regulator BOK Gene

BOK - BCL2 family apoptosis regulator BOK Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：BCL2 家族细胞凋亡调节因子 BOK

种属: Homo sapiens

同用名: BOKL; BCL2L9

基因 ID: 666 | 基因类型: protein coding

关于 BOK

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,551,393-241,574,131 (from NCBI)

This gene has 2 transcripts (splice variants), 265 orthologues and 8 paralogues. Broad expression in fat (RPKM 69.1), liver (RPKM 18.4) and 16 other tissues.

功能概要

该基因编码的蛋白质属于 BCL2 家族，其成员形成同二聚体或异二聚体，并作为参与多种细胞过程的抗凋亡或促凋亡调节剂。对大鼠的研究表明，该蛋白在生殖组织中的表达受到限制，与一些抗凋亡 BCL2 蛋白相互作用强烈，与促凋亡 BCL2 蛋白完全不相互作用，并在转染细胞中诱导细胞凋亡。因此，该蛋白质代表 BCL2 家族的促凋亡成员。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces Apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]

BOK 基因产物(1)

mRNA Protein Name
NM_032515.5 NP_115904.1 bcl-2-related ovarian killer protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15868100 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
20673843 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
15102863 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
15102863 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
16302269 GOA
involved in positive regulation of execution phase of apoptosis IMP
IMP: 通过突变表型推断
20673843 GOA
involved in regulation of autophagy IMP
IMP: 通过突变表型推断
24113155 GOA
involved in regulation of chorionic trophoblast cell proliferation IDA
IDA: 通过直接分析推断
19942931 GOA
involved in regulation of granulosa cell apoptotic process IMP
IMP: 通过突变表型推断
20673843 GOA
involved in release of cytochrome c from mitochondria IDA
IDA: 通过直接分析推断
27505430 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
27505430 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15868100 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
16302269 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
27505430 GOA
located in membrane IDA
IDA: 通过直接分析推断
19942931 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
24113155 GOA
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
15868100 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
15102863 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16302269 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BOK 蛋白结构

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (70 - 171)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

bcl-2-related ovarian killer protein

BCL2 related ovarian killer

BOK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
BOK Q9UMX3 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
种属内
BOK Q9UMX3 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
种属内
BOK Q9UMX3 PECAM1 Homo sapiens P16284
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

BOK 抗体

目录号 产品名 应用 反应物种
HY-P82544 Bok Antibody (YA2289) WB Human, Rat

关联疾病

疾病名称 别名
Retinitis Pigmentosa 71

RP71

Retinitis Pigmentosa, Type 71
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01570 BOK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus BOK VGNC VGNC:60146
Bos taurus BOK VGNC VGNC:26538
Rattus norvegicus BOK RGD RGD:70984
Mus musculus BOK MGD MGI:1858494
Macaca mulatta BOK VGNC VGNC:104511
Others BOK NCBI
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