1. Gene
  2. SPOCK1 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Gene

SPOCK1 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Gene

中文名称:SPARC (骨连蛋白) 、cwcv 和 kazal 样结构域蛋白聚糖 1

种属: Homo sapiens

同用名: TIC1; SPOCK; TESTICAN

基因 ID: 6695 | 基因类型: protein coding

关于 SPOCK1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:136,975,298-137,499,326 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 74.1), prostate (RPKM 36.6) and 10 other tissues.

功能概要

该基因编码含有软骨素和硫酸乙酰肝素链的精浆蛋白聚糖的核心蛋白。该蛋白质的功能未知,但与甲状腺素型半胱氨酸蛋白酶抑制剂的相似性表明其功能可能与蛋白酶抑制有关。[RefSeq 提供,2008 年 7 月]

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to Protease inhibition. [provided by RefSeq, Jul 2008]

SPOCK1 基因产物(1)

mRNA Protein Name
NM_004598.4 NP_004589.1 testican-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
9323035 GOA
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
14511383 GOA
enables metalloendopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
11751414 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
12853036 GOA
involved in negative regulation of endopeptidase activity IDA
IDA: 通过直接分析推断
14511383 GOA
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
12853036 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
14511383 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SPOCK1 蛋白结构

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (139 - 180)

SPARC_Ca_bdg

SPARC_Ca_bdg: Secreted protein acidic and rich in cysteine Ca binding region (196 - 304)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (313 - 376)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 439 a.a.
蛋白主名 其他名称

testican-1

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1

重组 SPOCK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76654 Testican 1/SPOCK1 Protein, Human (sf9, His) Q08629 (M1-W439) ≥95%

关联疾病

疾病名称 别名
Deafness, Autosomal Recessive 101

DFNB101

Autosomal Recessive Nonsyndromic Deafness 101

Autosomal Recessive Deafness 101

Deafness, Autosomal Recessive, 101

Deafness, Autosomal Recessive, Type 101

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SPOCK1 MGD MGI:105371
Canis familiaris SPOCK1 VGNC VGNC:59043
Rattus norvegicus SPOCK1 RGD RGD:1311496
Felis catus SPOCK1 VGNC VGNC:102331
Macaca mulatta SPOCK1 VGNC VGNC:84514
Others SPOCK1 NCBI