2. Gene
  3. SULT1E1 - sulfotransferase family 1E member 1 Gene

SULT1E1 - sulfotransferase family 1E member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磺基转移酶家族 1E 成员 1

种属: Homo sapiens

同用名: EST; STE; EST-1; ST1E1

基因 ID: 6783 | 基因类型: protein coding

关于 SULT1E1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,821,122-69,860,145 (from NCBI)

This gene has 2 transcripts (splice variants), 616 orthologues and 12 paralogues. Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues.

功能概要

磺基转移酶催化许多激素、神经递质、药物和异生化合物的硫酸盐结合。这些胞质酶的组织分布和底物特异性不同。家族成员之间的基因结构 (外显子的数量和长度) 相似。该基因编码一种蛋白质，该蛋白质可将磺基部分转移到雌酮和从雌酮转移，这可能控制雌激素受体的水平。[RefSeq 提供，2008 年 7 月]

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]

SULT1E1 基因产物(1)

mRNA Protein Name
NM_005420.3 NP_005411.1 sulfotransferase 1.00E+01
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables flavonol 3-sulfotransferase activity IDA
IDA: 通过直接分析推断
20056724 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables steroid sulfotransferase activity IDA
IDA: 通过直接分析推断
11884392 GOA
enables sulfotransferase activity IDA
IDA: 通过直接分析推断
19548878 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: 通过直接分析推断
23207770 GOA
involved in estrogen catabolic process IDA
IDA: 通过直接分析推断
23207770 GOA
involved in estrogen metabolic process IDA
IDA: 通过直接分析推断
11884392 GOA
involved in ethanol catabolic process IDA
IDA: 通过直接分析推断
23207770 GOA
involved in positive regulation of fat cell differentiation IMP
IMP: 通过突变表型推断
24567372 GOA
acts upstream of or within sulfation IDA
IDA: 通过直接分析推断
19548878 GOA
involved in sulfation IDA
IDA: 通过直接分析推断
20056724 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SULT1E1 蛋白结构

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (37 - 286)

  • 0
  • 100
  • 200
  • 294 a.a.
蛋白主名 其他名称

sulfotransferase 1E1

estrogen sulfotransferase

SULT1E1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SULT1E1 P49888 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
32296183
种属内
SULT1E1 P49888 PDE9A Homo sapiens O76083-2
Y2H Array
32296183
种属内
SULT1E1 P49888 PDE9A Homo sapiens O76083
Validated Y2H
25416956
种属内
SULT1E1 P49888 PDE9A Homo sapiens O76083
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SULT1E1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76099 SULT1E1 Protein, Human (His) P49888 (N2-I294) ≥95%

关联疾病

疾病名称 别名
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Skin Angiosarcoma

Angiosarcoma Of Skin

Hemangiosarcoma Of The Skin

Haemangiosarcoma Of Skin

Lymphangiosarcoma Of Skin

Cutaneous Angiosarcoma

Malignant Haemangioendothelioma Of Skin
Estrogen Excess

Hyperestrogenism
Clear Cell Adenoma
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Breast Disease

Breast Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14019 SULT1E1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SULT1E1 MGD MGI:98431
Rattus norvegicus SULT1E1 RGD RGD:3776
Macaca mulatta SULT1E1 VGNC VGNC:100275
Bos taurus SULT1E1 VGNC VGNC:35467
Others SULT1E1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z