2. Gene
  3. NEK4 - NIMA related kinase 4 Gene

NEK4 - NIMA related kinase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NIMA 相关激酶 4

种属: Homo sapiens

同用名: NRK2; STK2; pp12301

基因 ID: 6787 | 基因类型: protein coding

关于 NEK4

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,708,444-52,770,940 (from NCBI)

This gene has 7 transcripts (splice variants), 204 orthologues and 35 paralogues. Broad expression in testis (RPKM 13.9), thyroid (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是正常进入复制衰老所需的丝氨酸/苏氨酸蛋白激酶。编码的蛋白质还参与响应双链 DNA 损伤的细胞周期停滞。最后，这种蛋白质在维持纤毛完整性方面发挥作用，并且该基因的缺陷与纤毛病有关。[RefSeq 提供，2017 年 1 月]

The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017]

NEK4 基因产物(5)

mRNA Protein Name
NM_001193533.3 NP_001180462.1 serine/threonine-protein kinase Nek4 isoform 2
NM_001348412.2 NP_001335341.1 serine/threonine-protein kinase Nek4 isoform 3
NM_001348413.2 NP_001335342.1 serine/threonine-protein kinase Nek4 isoform 4
NM_001348414.2 NP_001335343.1 serine/threonine-protein kinase Nek4 isoform 5
NM_003157.6 NP_003148.2 serine/threonine-protein kinase Nek4 isoform 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
22851694 GOA
involved in mitotic cell cycle IMP
IMP: 通过突变表型推断
22851694 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
22851694 GOA
involved in regulation of cellular senescence IMP
IMP: 通过突变表型推断
22851694 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEK4 蛋白结构

Pkinase

Pkinase: Protein kinase domain (7 - 261)

  • 0
  • 200
  • 400
  • 600
  • 841 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Nek4

NIMA (never in mitosis gene a)-related kinase 4

NEK4 抗体

目录号 产品名 应用 反应物种
HY-P81613 NEK4 Antibody (YA1358) WB Human

关联疾病

疾病名称 别名
Ciliopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09195 NEK4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NEK4 RGD RGD:1304995
Felis catus NEK4 VGNC VGNC:80635
Canis familiaris NEK4 VGNC VGNC:43732
Macaca mulatta NEK4 VGNC VGNC:81483
Bos taurus NEK4 VGNC VGNC:31995
Mus musculus NEK4 MGD MGI:1344404
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