SULT2A1 - sulfotransferase family 2A member 1 Gene

中文名称：磺基转移酶家族 2A 成员 1

种属: Homo sapiens

同用名: HST; ST2; STD; hSTa; DHEAS; ST2A1; ST2A3; DHEA-ST; SULT2A3; DHEA-ST8

基因 ID: 6822 | 基因类型: protein coding

关于 SULT2A1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:47,870,467-47,886,315 (from NCBI)

This gene has 1 transcript (splice variant), 781 orthologues and 12 paralogues. Biased expression in liver (RPKM 300.0), adrenal (RPKM 86.0) and 2 other tissues.

功能概要

该基因编码磺基转移酶家族的一个成员。磺基转移酶通过将这些物质转化为更亲水的水溶性硫酸盐结合物，从而帮助药物和内源性化合物的代谢，这些结合物可以很容易地排出体外。这种蛋白质催化肝脏和肾上腺中类固醇和胆汁酸的硫酸化，并且可能在患有多囊卵巢综合征的女性的遗传性肾上腺雄激素过多中起作用。[RefSeq 提供，2010 年 3 月]

This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of Steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010]

SULT2A1 基因产物(1)

mRNA	Protein	Name
NM_003167.4	NP_003158.2	sulfotransferase 2A1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA IDA: 通过直接分析推断	10854859	GOA
enables alcohol sulfotransferase activity	IDA IDA: 通过直接分析推断	7854148	GOA
enables bile-salt sulfotransferase activity	IDA IDA: 通过直接分析推断	1588921	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21988832	GOA
enables steroid sulfotransferase activity	IDA IDA: 通过直接分析推断	23207770	GOA
enables steroid sulfotransferase activity	IMP IMP: 通过突变表型推断	29671343	GOA
enables sulfotransferase activity	IDA IDA: 通过直接分析推断	19548878	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: 通过直接分析推断	23207770	GOA
involved in cholesterol metabolic process	IDA IDA: 通过直接分析推断	19589875	GOA
involved in ethanol catabolic process	IDA IDA: 通过直接分析推断	23207770	GOA
involved in steroid metabolic process	IDA IDA: 通过直接分析推断	1588921	GOA
involved in steroid metabolic process	IMP IMP: 通过突变表型推断	29671343	GOA
acts upstream of or within sulfation	IDA IDA: 通过直接分析推断	19548878	GOA
involved in sulfation	IDA IDA: 通过直接分析推断	20056724	GOA
involved in thyroid hormone metabolic process	IDA IDA: 通过直接分析推断	10199779	GOA
involved in xenobiotic metabolic process	IDA IDA: 通过直接分析推断	7854148	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	2268288	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SULT2A1 蛋白结构

Sulfotransfer_1

0
100
200
285 a.a.

蛋白主名

其他名称

sulfotransferase 2A1

alcohol/hydroxysteroid sulfotransferase

SULT2A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SULT2A1	Q06520	SULT1B1	Homo sapiens	O43704	Y2H Prey Pooling	32296183
种属内	SULT2A1	Q06520	SULT1B1	Homo sapiens	O43704	Y2H Array	32296183
种属内	SULT2A1	Q06520	STAT3	Homo sapiens	P40763	Y2H	21988832
种属内	SULT2A1	Q06520	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
种属内	SULT2A1	Q06520	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
种属内	SULT2A1	Q06520	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SULT2A1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71343	SULT2A1 Protein, Human (His)	Q06520 (S2-E285)	≥95%

SULT2A1 抗体

目录号	产品名	应用	反应物种
HY-P82116	Sulfotransferase 2A1 Antibody (YA1861)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Mixed Epithelial Stromal Tumour

Adrenal Cortical Adenoma

Adrenocortical Adenoma

Adenoma Adrenocortical

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovarian Disease	Polycystic Ovaries
Stein-Leventhal Syndrome	Multicystic Ovaries
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis	PSC
Sclerosing Cholangitis	Cholangitis, Sclerosing
Cholangitis Primary Sclerosing	Psc - [Primary Sclerosing Cholangitis]

Cortisone Reductase Deficiency

11-Alpha Beta-Hydroxysteroid Dehydrogenase Type I Deficiency Of	Cortrd
Hsd 11b1 Deficiency

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma	Adrenal Cortex Carcinoma
Carcinoma Of The Adrenal Cortex	Acc
Adrenocortical Cancer	Carcinoma Adrenocortical

Adult Hepatocellular Carcinoma

Adult Primary Hepatocellular Carcinoma	Adult Hepatoma
Adult Hcc

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy	Gravidic Intrahepatic Cholestasis
Pregnancy-Related Cholestasis	Icp
Pregnancy Related Cholestasis	Cholestasis, Intrahepatic Of Pregnancy
Familial Intrahepatic Cholestasis Of Pregnancy	Familial Recurrent Intrahepatic Cholestasis Of Pregnancy
Ricp	Obstetric Cholestasis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14020	SULT2A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14021	SULT2B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SULT2A1	RGD	RGD:621337
Macaca mulatta	SULT2A1	VGNC	VGNC:78053
Others	SULT2A1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SULT2A1 - sulfotransferase family 2A member 1 Gene

关于 SULT2A1

功能概要

SULT2A1 基因产物(1)

SULT2A1 蛋白结构

SULT2A1 蛋白互作信息

重组 SULT2A1 蛋白

SULT2A1 抗体

关联疾病

直系同源

热门区域

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SULT2A1 - sulfotransferase family 2A member 1 Gene

关于 SULT2A1

功能概要

SULT2A1 基因产物(1)

SULT2A1 蛋白结构

SULT2A1 蛋白互作信息

重组 SULT2A1 蛋白

SULT2A1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z