2. Gene
  3. BST1 - bone marrow stromal cell antigen 1 Gene

BST1 - bone marrow stromal cell antigen 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：骨髓基质细胞抗原 1

种属: Homo sapiens

同用名: CD157; cADPR2

基因 ID: 683 | 基因类型: protein coding

关于 BST1

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,703,065-15,774,173 (from NCBI)

This gene has 5 transcripts (splice variants), 117 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 14.1), duodenum (RPKM 6.3) and 23 other tissues.

功能概要

骨髓基质细胞抗原 1 是基质细胞系衍生的糖基磷脂酰肌醇锚定分子，可促进前 B 细胞生长。推导的氨基酸序列与 CD38 具有 33% 的相似性。 BST1 表达在源自类风湿性关节炎患者的骨髓基质细胞系中增强。类风湿性关节炎中的多克隆 B 细胞异常可能至少部分归因于 BST1 在基质细胞群中的过度表达。[RefSeq 提供，2008 年 7 月]

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

BST1 基因产物(1)

mRNA Protein Name
NM_004334.3 NP_004325.2 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+ nucleotidase, cyclic ADP-ribose generating IDA
IDA: 通过直接分析推断
7805847 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
8202488 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
15328157 GOA
involved in regulation of calcium-mediated signaling IMP
IMP: 通过突变表型推断
15328157 GOA
involved in regulation of cell-matrix adhesion IDA
IDA: 通过直接分析推断
15328157 GOA
involved in regulation of inflammatory response IDA
IDA: 通过直接分析推断
15328157 GOA
involved in regulation of neutrophil chemotaxis IDA
IDA: 通过直接分析推断
15328157 GOA
involved in regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8941363 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
8202488 GOA
located in uropod IDA
IDA: 通过直接分析推断
15328157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BST1 蛋白结构

Rib_hydrolayse

Rib_hydrolayse: ADP-ribosyl cyclase (41 - 280)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
蛋白主名 其他名称

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

ADP-ribosyl cyclase 2

重组 BST1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7791 CD157 Protein, Human (HEK293, His) Q10588 (G29-K292) ≥95%
HY-P7792 CD157 Protein, Human (HEK293, Fc) Q10588 (G29-K292) ≥95%

关联疾病

疾病名称 别名
Paroxysmal Nocturnal Hemoglobinuria

Marchiafava-Micheli Disease

Pnh

Hemoglobinuria, Paroxysmal

Marchiafava-Micheli Syndrome

Paroxysmal Hemoglobinuria Nocturnal

Nocturnal Haemoglobinuria

Nocturnal Paroxysmal Haematuria

Nocturnal Paroxysmal Haemoglobinaemia
Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder

Rem Sleep Behaviour Disorder

Rapid Eye Movement Sleep Behaviour Disorder

Rem - [Rapid Eye Movement] Behaviour Disorder
Hemoglobinuria
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01648 BST1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus BST1 MGD MGI:105370
Rattus norvegicus BST1 RGD RGD:620344
Felis catus BST1 VGNC VGNC:60191
Macaca mulatta BST1 VGNC VGNC:70285
Canis familiaris BST1 VGNC VGNC:38541
Bos taurus BST1 VGNC VGNC:26581
Macaca fascicularis BST1 NCBI NCBI:101926698
Others BST1 NCBI
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