SVIL - supervillin Gene

中文名称：超级恶棍

种属: Homo sapiens

同用名: MFM10

关于 SVIL

功能概要

该基因编码具有不同氨基和羧基末端结构域的二分蛋白。氨基末端包含核定位信号，羧基末端包含许多连续序列，与肌动蛋白结合蛋白的凝溶胶蛋白家族中的蛋白质具有广泛的相似性，可加盖、成核和/或切断肌动蛋白丝。该基因产物与肌动蛋白丝和质膜紧密相关，表明其在肌动蛋白细胞骨架和膜之间具有高亲和力联系。编码的蛋白质似乎有助于细胞扩散和粘着斑分解过程中的肌球蛋白 II 组装。已经描述了几种编码不同同种型 supervillin 的转录物变体。[RefSeq 提供，2016 年 4 月]

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin Cytoskeleton and the membrane. The encoded protein appears to aid in both Myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]