TAC3 - tachykinin precursor 3 Gene

中文名称：速激肽前体 3

种属: Homo sapiens

同用名: NK3; NKB; HH10; NKNB; PRO1155; ZNEUROK1; LncZBTB39

基因 ID: 6866 | 基因类型: protein coding

关于 TAC3

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,010,000-57,016,529 (from NCBI)

This gene has 10 transcripts (splice variants), 158 orthologues and is associated with 3 phenotypes. Restricted expression toward placenta (RPKM 93.9).

功能概要

该基因编码分泌神经肽速激肽家族的成员。编码的前原蛋白经过蛋白水解处理以生成成熟肽，该肽主要在中枢和周围神经系统中表达，并作为神经递质发挥作用。该肽是神经激肽 3 受体的配体。这种蛋白质也在胎盘的外层合体滋养细胞中表达，可能与妊娠高血压和先兆子痫有关。该基因的突变与正常低促性腺激素性腺功能减退症有关。可变剪接导致多个转录本变体，其中至少一个编码一种经过蛋白水解处理的亚型。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

TAC3 基因产物(2)

mRNA	Protein	Name
NM_001178054.2	NP_001171525.1	tachykinin-3 isoform 2 precursor
NM_013251.4	NP_037383.1	tachykinin-3 isoform 1 preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables neuromedin K receptor binding	IPI IPI: 通过物理相互作用推断	12716968	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23597562	GOA
enables substance K receptor binding	IPI IPI: 通过物理相互作用推断	12716968	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of flagellated sperm motility	IDA IDA: 通过直接分析推断	17437961	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	17437961	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TAC3 蛋白结构

Neurokinin_B

0
100
121 a.a.

蛋白主名

其他名称

tachykinin-3

LncZBTB39-1:2

TAC3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TAC3	Q9UHF0	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
种属内	TAC3	Q9UHF0	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
种属内	TAC3	Q9UHF0	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TAC3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71349	Tachykinin-3 Protein, Human (His)	Q9UHF0 (Q17-E121)	≥95%

关联疾病

疾病名称

别名

Hypogonadotropic Hypogonadism 10 With Or Without Anosmia

HH10	Hypogonadotropic Hypogonadism 10 Without Anosmia
Hypogonadism, Hypogonadotropic, Type 10 With/Without Anosmia

Infertility

Normosmic Congenital Hypogonadotropic Hypogonadism

Normosmic Idiopathic Hypogonadotropic Hypogonadism

Nihh

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Hypogonadism

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Central Precocious Puberty

Cpp	Gonadotropin-Dependant Precocious Puberty
Gonadotropin-Dependent Precocious Puberty	Precocious Puberty, Central

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Constipation

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Renal Hypodysplasia/Aplasia 1

Renal Agenesis	Renal Adysplasia
Renal Aplasia	RHDA1
Hereditary Renal Aplasia	Hra
Hereditary Urogenital Adysplasia	Hypodysplasia/Aplasia, Renal, Type 1
Congenital Absence Of Kidneys Syndrome	Congenital Absence Of Kidney
Aplastic Kidney

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14137	TAC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TAC3	MGD	MGI:98476
Canis familiaris	TAC3	VGNC	VGNC:47062
Macaca mulatta	TAC3	VGNC	VGNC:78079
Rattus norvegicus	TAC3	RGD	RGD:3809
Bos taurus	TAC3	VGNC	VGNC:35556
Felis catus	TAC3	VGNC	VGNC:65916
Others	TAC3	NCBI

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