Haspin - histone H3 associated protein kinase Gene

中文名称：组蛋白 H3 相关蛋白激酶

种属: Rattus norvegicus

同用名: Gsg2

关于 Haspin

功能概要

预测该基因编码的蛋白可启动 ATP 绑定活动； DNA结合活性；和组蛋白激酶活性（H3-T3 特异性）。预测参与组蛋白 H3-T3 磷酸化，参与染色体乘客复合体定位到着丝粒；细胞内信号转导；与有丝分裂姐妹染色单体的凝聚。预计在有丝分裂细胞周期的 G1/S 转换的负调节上游或负调节内起作用。预计位于中心体；核质；和主轴。预计在细胞质和细胞核中有活性。与人类 HASPIN（组蛋白 H3 相关蛋白激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; DNA binding activity; and histone kinase activity (H3-T3 specific). Predicted to be involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; and mitotic sister chromatid cohesion. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in centrosome; nucleoplasm; and spindle. Predicted to be active in cytoplasm and nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Apr 2022]