2. Gene
  3. HASPIN - histone H3 associated protein kinase Gene

HASPIN - histone H3 associated protein kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白 H3 相关蛋白激酶

种属: Homo sapiens

同用名: GSG2

基因 ID: 83903 | 基因类型: protein coding

关于 HASPIN

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,723,903-3,726,699 (from NCBI)

This gene has 1 transcript (splice variant), 174 orthologues and 4 paralogues.

功能概要

启用 ATP 结合活性和组蛋白激酶活性 (H3-T3 特异性) 。参与组蛋白 H3-T3 磷酸化，参与染色体乘客复合体定位到着丝粒；细胞内信号转导；与有丝分裂姐妹染色单体的凝聚。位于中心体；核质；和主轴。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and histone kinase activity (H3-T3 specific). Involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; and mitotic sister chromatid cohesion. Located in centrosome; nucleoplasm; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

HASPIN 基因产物(1)

mRNA Protein Name
NM_031965.2 NP_114171.2 serine/threonine-protein kinase haspin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
11228240 GOA
enables histone H3T3 kinase activity IMP
IMP: 通过突变表型推断
15681610 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19918049 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
11228240 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
11228240 GOA
involved in mitotic sister chromatid cohesion IMP
IMP: 通过突变表型推断
20705812 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: 通过突变表型推断
23071153 GOA
involved in protein localization to chromosome, centromeric region IMP
IMP: 通过突变表型推断
20705812 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11228240 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
11228240 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11228240 GOA
located in spindle IDA
IDA: 通过直接分析推断
15681610 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HASPIN 蛋白结构

Pkinase

Pkinase: Protein kinase domain (486 - 687)

Haspin_kinase

Haspin_kinase: Haspin like kinase domain (708 - 797)

  • 0
  • 200
  • 400
  • 600
  • 798 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase haspin

H-haspin

germ cell associated 2, haspin

germ cell-specific gene 2 protein

haploid germ cell-specific nuclear protein kinase

HASPIN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HASPIN Q8TF76 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
HASPIN Q8TF76 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
HASPIN Q8TF76 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属内
HASPIN Q8TF76 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
种属内
HASPIN Q8TF76 MDFI Homo sapiens Q99750
Y2H Array
32296183
种属内
HASPIN Q8TF76 MDFI Homo sapiens Q99750
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15424 5-Iodotubercidin Inhibitor 99.64% 否
HY-15217 CHR-6494 Inhibitor 98.07% 否
HY-13455 LDN-192960 Inhibitor 99.56% 否
HY-146636 Haspin-IN-3 Inhibitor 98.14% 否
HY-110320 LDN-209929 dihydrochloride Inhibitor ≥99.0% 否
HY-13455A LDN-192960 hydrochloride Inhibitor 99.78% 否
HY-100368 MELK-8a Inhibitor 98.32% 否
HY-110350 CHR-6494 TFA Inhibitor / 否
HY-146586 Haspin-IN-1 Inhibitor / 否
HY-146587 Haspin-IN-2 Inhibitor / 否
HY-155341 HSK205 Inhibitor / 否
HY-163858 Haspin-IN-4 Inhibitor / 否
HY-170546 MU1920 Inhibitor / 否
HY-RS06009 HASPIN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06010 Haspin Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06011 Haspin Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-135002 LDN-209929 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HASPIN MGD MGI:1194498
Bos taurus HASPIN VGNC VGNC:55834
Macaca mulatta HASPIN VGNC VGNC:104614
Canis familiaris HASPIN VGNC VGNC:49092
Felis catus HASPIN VGNC VGNC:62754
Rattus norvegicus HASPIN RGD RGD:1596276
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