2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. Haspin Kinase CDK DYRK
  4. Haspin-IN-2

Haspin-IN-2 (compound 4) 是一种有效的选择性的 haspin 抑制剂，IC50 为 50 nM。Haspin-IN-1 还抑制 CLK1 和 DYRK1A，IC50 分别为 445 nM 和 917 nM。

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Haspin-IN-2 Chemical Structure

Haspin-IN-2 Chemical Structure

CAS No. : 2768474-47-9

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Haspin-IN-2 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

查看 DYRK 亚型特异性产品:

查看所有亚型
DYRK1 DYRK2 DYRK3 DYRK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Haspin-IN-2 (compound 4) is a potent and selective haspin inhibitor with an IC50 of 50 nM. Haspin-IN-1 also inbibits CLK1 and DYRK1A with IC50s of 445 nM and 917 nM, respectively[1].

IC50 & Target[1]

Haspin Kinase

50 nM (IC50)

CLK1

445 nM (IC50)

DYRK1A

917 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HBL-100 EC50
8.5 μM
Compound: 4
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HBL-100 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
HCT-116 EC50
6.2 μM
Compound: 4
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
SH-SY5Y EC50
4.4 μM
Compound: 4
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
TERT-RPE1 EC50
3.2 μM
Compound: 4
Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human TERT-RPE1 cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
U2OS EC50
5.8 μM
Compound: 4
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 48 hrs by MTS assay
[PMID: 35447555]
分子量

256.22

Formula

C12H8N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Haspin-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Haspin-IN-22768474-47-9Haspin KinaseCDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCLK1DYRK1AanticancerInhibitorinhibitorinhibit

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