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  2. TAL2 - TAL bHLH transcription factor 2 Gene

TAL2 - TAL bHLH transcription factor 2 Gene

中文名称:TAL bHLH 转录因子 2

种属: Homo sapiens

基因 ID: 6887 | 基因类型: protein coding

关于 TAL2

Cytogenetic location: 9q31.2 Genomic coordinates (GRCh38): 9:105,662,457-105,663,124 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues, 4 paralogues and is associated with 30 phenotypes.

功能概要

这种无内含子的基因编码一种螺旋-环-螺旋蛋白。 9 号染色体上的该基因与 7 号染色体上的 T 细胞受体 β 链位点之间的易位与 T 细胞急性淋巴细胞白血病 2 基因和 T 细胞急性淋巴细胞白血病的激活有关。[RefSeq 提供,2009 年 3 月]

This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

TAL2 基因产物(1)

mRNA Protein Name
NM_005421.3 NP_005412.1 T-cell acute lymphocytic leukemia protein 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAL2 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (6 - 54)

  • 0
  • 100
  • 108 a.a.
蛋白主名 其他名称

T-cell acute lymphocytic leukemia protein 2

T-cell acute lymphocytic leukemia 2

TAL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAL2 Q16559 TCF4 Homo sapiens P15884
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Mixed Phenotype Acute Leukemia, B/Myeloid

Doid:0081038

Childhood T-Cell Acute Lymphoblastic Leukemia

T-Cell Childhood Acute Lymphoblastic Leukemia

Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia

T-Cell Childhood Acute Lymphocytic Leukemia

Childhood T Lymphoblastic Leukemia/Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TAL2 VGNC VGNC:65946
Macaca mulatta TAL2 VGNC VGNC:78095
Mus musculus TAL2 MGD MGI:99540
Bos taurus TAL2 VGNC VGNC:35589
Canis familiaris TAL2 VGNC VGNC:47097
Rattus norvegicus TAL2 RGD RGD:1596467