TCN1 - transcobalamin 1 Gene

中文名称：钴胺素 1

种属: Homo sapiens

同用名: HC; TC1; TCI; TC-1

基因 ID: 6947 | 基因类型: protein coding

关于 TCN1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,852,808-59,866,487 (from NCBI)

This gene has 5 transcripts (splice variants), 97 orthologues and 2 paralogues. Biased expression in salivary gland (RPKM 166.7), gall bladder (RPKM 102.9) and 3 other tissues.

功能概要

该基因编码维生素 B12 结合蛋白家族的一个成员。这个蛋白质家族，也称为 R 结合物，在各种组织和分泌物中表达。这种蛋白质是嗜中性粒细胞次级颗粒的主要成分，有助于将钴胺素转运到细胞中。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

TCN1 基因产物(1)

mRNA	Protein	Name
NM_001062.4	NP_001053.2	transcobalamin-1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cargo receptor ligand activity	EXP EXP: 通过实验结果推断	22547309	GOA
enables molecular sequestering activity	EXP EXP: 通过实验结果推断	23846701	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TCN1 蛋白结构

Cobalamin_bind

DUF4430

0
100
200
300
400
433 a.a.

蛋白主名

其他名称

transcobalamin-1

haptocorin

重组 TCN1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71789	TCN1 Protein, Human (P.pastoris, His)	P20061 (24E-433Y)	≥95%

关联疾病

疾病名称

别名

Transcobalamin I Deficiency

Tcn1 Deficiency	Cobalamin Pseudodeficiency Due To Transcobalamin Deficiency
Cobalamin R Binder Protein Deficiency	Transcobalamin 1 Deficiency
Haptocorrin Deficiency	Tci Deficiency
Transcobalamin-1 Deficiency

Vitamin B12 Deficiency

Cobalamin Deficiency	Hypocobalaminemia
Vitamin B 12 Deficiency	Cyanocobalamin Deficiency
Deficiency Of Vitamin B12

Vitamin Metabolic Disorder

Transcobalamin Ii Deficiency

TCN2 DEFICIENCY	Tc Ii Deficiency
Transcobalamin Deficiency	Tc Deficiency
Inherited Deficiency Of Transcobalamin

Megaloblastic Anemia

Imerslund-Grasbeck Syndrome	Igs
Defect Of Enterocyte Intrinsic Factor Receptor	Enterocyte Cobalamin Malabsorption
Familial Megaloblastic Anemia	Megaloblastic Anemia 1
Selective Cobalamin Malabsorption With Proteinuria	Imerslund-Gräsbeck Syndrome
Anemia, Megaloblastic	Grasbeck-Imerslund Syndrome
Megaloblastic Anaemia	Mga1 Norwegian Type
Recessive Hereditary Megaloblastic Anaemia 1	Recessive Hereditary Megaloblastic Anemia 1
Rh-Mga1	Gräsbeck-Imerslund Disease
Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria	Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12
Anemia Megaloblastic	Megaloblastic Anemia Due To Inborn Errors Of Metabolism
3-@Methylglutaconic Aciduria, Type I

Tropical Sprue

Tropical Steatorrhea	Tropical Enteropathy
Sprue, Tropical	Sprue - Tropical
Idiopathic Tropical Malabsorption Syndrome	Tropical Steatorrhoea
Tropical Diarrhoea	Ts - [Tropical Sprue]
Psilosis	Sprue Nos

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Pernicious Anemia

Anemia, Pernicious	Anemia Pernicious
Pernicious Anaemia	Addison'S Anaemia
Biermer'S Anaemia	Biermer'S Anemia
Acquired Pernicious Anemia	Addison-Biermer Anemia
Addisonian Anemia	Biermer Anemia
Biermer'S Disease	Juvenile Onset Pernicious Anemia
Biermer Disease	Biermer-Addison Disease

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Diphyllobothriasis

Diphyllobothrium Infection	Fish Tapeworm
Bothriocephalosis	Infection By Bothriocephalus
Fish Tapeworm Infection	Dibothriocephalus Anaemia
Dibothriocephaliasis	Broad Tapeworm Infection
Bothriocephaliasis	Dibothriocephalus
Intestinal Diphyllobothriasis	Diphyllobothrium Infestation
Dibothriocephalus Infestation	Bothriocephalus Infestation
Adult Diphyllobothrium Infection	Tapeworm Anaemia
Infection By Diphyllobothrium Larvae

Blind Loop Syndrome

Bacterial Overgrowth Syndrome

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

Methylmalonic Acidemia

Methylmalonic Aciduria	Mma
Acidemia, Methylmalonic	Isolated Methylmalonic Acidemia

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14318	TCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TCN1	NCBI
Rattus norvegicus	TCN1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TCN1 - transcobalamin 1 Gene

关于 TCN1

功能概要

TCN1 基因产物(1)

TCN1 蛋白结构

重组 TCN1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TCN1 - transcobalamin 1 Gene

关于 TCN1

功能概要

TCN1 基因产物(1)

TCN1 蛋白结构

重组 TCN1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z