2. Gene
  3. Hjv - hemojuvelin BMP co-receptor Gene

Hjv - hemojuvelin BMP co-receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: DL-M; Hfe2; Rgmc; hemojuvelin; 2310035L15Rik; 5230400G09Rik

基因 ID: 69585 | 基因类型: protein coding

关于 Hjv

功能概要

Enables BMP binding activity and coreceptor activity. Involved in cellular iron ion homeostasis and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including BMP signaling pathway; iron ion homeostasis; and negative regulation of BMP signaling pathway. Located in cell surface and extracellular space. Is expressed in several structures, including gonad; musculature; submandibular gland; trunk mesenchyme; and yolk sac. Used to study hemochromatosis type 2A. Human ortholog(s) of this gene implicated in hemochromatosis and hemochromatosis type 2A. Orthologous to human HJV (hemojuvelin BMP co-receptor). [provided by Alliance of Genome Resources, Apr 2022]

Hjv 基因产物(1)

mRNA Protein Name
NM_027126.4 NP_081402.3 hemojuvelin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BMP binding IDA
IDA: 通过直接分析推断
16604073 MGI
enables BMP binding IPI
IPI: 通过物理相互作用推断
16604073 MGI
enables coreceptor activity IGI
IGI: 通过遗传相互作用推断
16604073 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
16604073 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: 通过突变表型推断
16604073 MGI
involved in intracellular iron ion homeostasis IMP
IMP: 通过突变表型推断
25860887 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IMP
IMP: 通过突变表型推断
16075058 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
20065295 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25860887 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18997172 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16604073 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19751239 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25860887 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18997172 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19751239 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
14749425 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
14749425 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hemojuvelin

RGM domain family member C

hemochromatosis type 2 (juvenile) (human homolog)

hemochromatosis type 2 protein homolog

hemojuvelin BMP coreceptor

repulsive guidance molecule C

重组 Hjv 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78029 RGM-C Protein, Mouse (HEK293, His) Q7TQ32-1 (G33-A393) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06191 HJV Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hjv NCBI NCBI:148738
Macaca fascicularis Hjv NCBI NCBI:102138915
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