TDGF1 - teratocarcinoma-derived growth factor 1 Gene

中文名称：畸胎癌衍生生长因子 1

种属: Homo sapiens

同用名: CR; CR-1; CRGF; CRIPTO

基因 ID: 6997 | 基因类型: protein coding

关于 TDGF1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,574,535-46,582,457 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues, 5 paralogues and is associated with 7 phenotypes. Biased expression in spleen (RPKM 9.5), kidney (RPKM 5.0) and 5 other tissues.

功能概要

该基因编码一种表皮生长因子相关蛋白，该蛋白包含一个 cripto、FRL-1 和隐蔽结构域。编码的蛋白质是一种细胞外膜结合信号蛋白，在胚胎发育和肿瘤生长中起着至关重要的作用。该基因的突变与前脑缺陷有关。该基因的假基因存在于染色体 2、3、6、8、19 和 X 上。交替剪接导致多个转录变体。[RefSeq 提供，2010 年 3 月]

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

TDGF1 基因产物(2)

mRNA	Protein	Name
NM_001174136.2	NP_001167607.1	teratocarcinoma-derived growth factor 1 isoform 2
NM_003212.4	NP_003203.1	teratocarcinoma-derived growth factor 1 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables growth factor activity	IDA IDA: 通过直接分析推断	8006041	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12919325	GOA
enables signaling receptor binding	IDA IDA: 通过直接分析推断	11909953	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell migration involved in sprouting angiogenesis	IMP IMP: 通过突变表型推断	17720976	GOA
involved in cellular response to epidermal growth factor stimulus	IDA IDA: 通过直接分析推断	17720976	GOA
involved in cellular response to fibroblast growth factor stimulus	IDA IDA: 通过直接分析推断	17720976	GOA
involved in cellular response to hepatocyte growth factor stimulus	IDA IDA: 通过直接分析推断	17720976	GOA
involved in cellular response to interleukin-6	IDA IDA: 通过直接分析推断	17720976	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	17720976	GOA
involved in cellular response to type II interferon	IDA IDA: 通过直接分析推断	17720976	GOA
NOT acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	8006041	GOA
involved in heart development	IDA IDA: 通过直接分析推断	9576836	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	10493495	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: 通过直接分析推断	10493495	GOA
acts upstream of or within positive regulation of MAP kinase activity	IDA IDA: 通过直接分析推断	9013573	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	9013573	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	12649175	GOA
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	8006041	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: 通过直接分析推断	17720976	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	10493495	GOA
involved in regulation of signal transduction	IDA IDA: 通过直接分析推断	12649175	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	17720976	GOA
located in cell surface	IDA IDA: 通过直接分析推断	12925698	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	17720976	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	17720976	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TDGF1 蛋白结构

CFC

0
100
188 a.a.

蛋白主名

其他名称

teratocarcinoma-derived growth factor 1

cripto-1 growth factor

重组 TDGF1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71112	TDGF1 Protein, Human (HEK293, Fc)	P13385 (L31-S169)	≥95%
HY-P700481	TDGF1 Protein, Human (GST)	P13385 (G32-D150)	≥95%

关联疾病

疾病名称

别名

Microform Holoprosencephaly

Hpe, Minor Form	Hpe-L
Holoprosencephaly, Minor Form	Holoprosencephaly-Like
Microform Hpe

Septopreoptic Holoprosencephaly

Septopreoptic Hpe

Midline Interhemispheric Variant Of Holoprosencephaly

Mih	Mih Type Hpe
Mihf	Mihv
Middle Interhemispheric Fusion Variant	Middle Interhemispheric Variant Of Holoprosencephaly
Syntelencephaly

Lobar Holoprosencephaly

Alobar Holoprosencephaly

Semilobar Holoprosencephaly

Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Charcot-Marie-Tooth Disease, X-Linked Dominant, 6

CMTX6	Charcot-Marie-Tooth Disease X-Linked Dominant 6
Cmt6x	X-Linked Charcot-Marie-Tooth Disease Type 6
Charcot-Marie-Tooth Neuropathy, X-Linked Dominant, 6	Charcot-Marie-Tooth Neuropathy X-Linked Dominant 6
Charcot-Marie-Tooth Neuropathy X-Linked 6	Charcot-Marie-Tooth Disease, X-Linked, Type 6

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14330	TDGF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TDGF1	MGD	MGI:98658
Rattus norvegicus	TDGF1	RGD	RGD:1594185

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TDGF1 - teratocarcinoma-derived growth factor 1 Gene

关于 TDGF1

功能概要

TDGF1 基因产物(2)

TDGF1 蛋白结构

重组 TDGF1 蛋白

关联疾病

直系同源

热门区域

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TDGF1 - teratocarcinoma-derived growth factor 1 Gene

关于 TDGF1

功能概要

TDGF1 基因产物(2)

TDGF1 蛋白结构

重组 TDGF1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z