1. Gene
  2. Cysltr2 - cysteinyl leukotriene receptor 2 Gene

Cysltr2 - cysteinyl leukotriene receptor 2 Gene

中文名称:半胱氨酰白三烯受体 2

种属: Mus musculus

同用名: Cltr2; Cyslt2; CYSLT2R; 2300001H05Rik

基因 ID: 70086 | 基因类型: protein coding

关于 Cysltr2

Chromosome 14: 73,263,043-73,286,554 reverse strand.GRCm39:CM001007.3

This gene has 5 transcripts (splice variants), 55 orthologues, 13 paralogues and is associated with 18 phenotypes. Broad expression in thymus adult (RPKM 1.4), spleen adult (RPKM .4) and 17 other tissues.

功能概要

该基因编码的蛋白可启动半胱氨酰白三烯受体活性。预计参与多个过程,包括神经肽信号通路; ERK1ERK2 级联的正调控;和血管生成的正调节。预测作用于 G 蛋白偶联受体信号通路的上游或内部。位于膜内。该基因的人类直系同源物与阿司匹林诱发的呼吸系统疾病和哮喘有关。与人 CYSLTR2(半胱氨酰白三烯受体 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables cysteinyl Leukotriene Receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of angiogenesis. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in membrane. Human ortholog(s) of this gene implicated in aspirin-induced respiratory disease and asthma. Orthologous to human CYSLTR2 (cysteinyl Leukotriene Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cysltr2 基因产物(2)

mRNA Protein Name
NM_001162412.2 NP_001155884.1 cysteinyl leukotriene receptor 2
NM_133720.4 NP_598481.2 cysteinyl leukotriene receptor 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteinyl leukotriene receptor activity IDA
IDA: 通过直接分析推断
11591709 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
11591709 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Cysltr2 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (22 - 299)

7tm_GPCRs

7tm_GPCRs: cd14964 (24 - 48)

7tm_GPCRs

7tm_GPCRs: cd14964 (57 - 78)

7tm_GPCRs

7tm_GPCRs: cd14964 (95 - 117)

7tm_GPCRs

7tm_GPCRs: cd14964 (140 - 156)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (229 - 251)

7tm_GPCRs

7tm_GPCRs: cd14964 (267 - 292)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

cysteinyl leukotriene receptor 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cysltr2 NCBI NCBI:57105