2. Gene
  3. TEP1 - telomerase associated protein 1 Gene

TEP1 - telomerase associated protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：端粒酶相关蛋白 1

种属: Homo sapiens

同用名: TP1; TLP1; p240; TROVE1; VAULT2

基因 ID: 7011 | 基因类型: protein coding

关于 TEP1

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,365,667-20,413,501 (from NCBI)

This gene has 11 transcripts (splice variants), 106 orthologues and 26 paralogues. Ubiquitous expression in duodenum (RPKM 11.6), small intestine (RPKM 7.0) and 24 other tissues.

功能概要

该基因产物是负责端粒酶活性的核糖核蛋白复合物的组分，端粒酶催化在染色体末端添加新的端粒。端粒酶相关蛋白从纤毛虫到人类都是保守的。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene product is a component of the ribonucleoprotein complex responsible for Telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

TEP1 基因产物(2)

mRNA Protein Name
NM_001319035.2 NP_001305964.1 telomerase protein component 1 isoform 2
NM_007110.5 NP_009041.2 telomerase protein component 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
15169895 GOA
enables p53 binding IPI
IPI: 通过物理相互作用推断
10597287 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
contributes to telomerase activity IDA
IDA: 通过直接分析推断
12135483 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in telomere maintenance via recombination IDA
IDA: 通过直接分析推断
10810353 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
7876352 GOA
located in nuclear matrix IDA
IDA: 通过直接分析推断
7876352 GOA
part of telomerase holoenzyme complex IDA
IDA: 通过直接分析推断
12135483 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TEP1 蛋白结构

TEP1_N

TEP1_N: TEP1 N-terminal domain (1 - 30)

TEP1_N

TEP1_N: TEP1 N-terminal domain (31 - 60)

TEP1_N

TEP1_N: TEP1 N-terminal domain (61 - 90)

TEP1_N

TEP1_N: TEP1 N-terminal domain (91 - 119)

TROVE

TROVE: TROVE domain (223 - 676)

DUF4062

DUF4062: Domain of unknown function (DUF4062) (901 - 981)

NACHT

NACHT: NACHT domain (1162 - 1335)

WD40

WD40: WD domain, G-beta repeat (1754 - 1787)

WD40

WD40: WD domain, G-beta repeat (1802 - 1826)

WD40

WD40: WD domain, G-beta repeat (1877 - 1912)

WD40

WD40: WD domain, G-beta repeat (2053 - 2089)

WD40

WD40: WD domain, G-beta repeat (2105 - 2134)

WD40

WD40: WD domain, G-beta repeat (2140 - 2174)

WD40

WD40: WD domain, G-beta repeat (2230 - 2265)

WD40

WD40: WD domain, G-beta repeat (2553 - 2581)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2627 a.a.
蛋白主名 其他名称

telomerase protein component 1

TROVE domain family, member 1

TEP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TEP1 Q99973 UBAP2 Homo sapiens Q5T6F2
Y2H Array
32296183
种属内
TEP1 Q99973 UBAP2 Homo sapiens Q5T6F2
Y2H Prey Pooling
32296183
种属内
TEP1 Q99973 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Campylobacteriosis

Campylobacter Infections

Campylobacter Infection

Enteric Campylobacteriosis
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14369 TEP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TEP1 VGNC VGNC:35745
Rattus norvegicus TEP1 RGD RGD:3869
Felis catus TEP1 VGNC VGNC:66079
Macaca mulatta TEP1 VGNC VGNC:78310
Canis familiaris TEP1 VGNC VGNC:47249
Mus musculus TEP1 MGD MGI:109573
Others TEP1 NCBI
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