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  2. TFPI - tissue factor pathway inhibitor Gene

TFPI - tissue factor pathway inhibitor Gene

中文名称:组织因子通路抑制因子

种属: Homo sapiens

同用名: EPI; TFI; LACI; TFPI1

基因 ID: 7035 | 基因类型: protein coding

关于 TFPI

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:187,464,230-187,554,435 (from NCBI)

This gene has 12 transcripts (splice variants), 167 orthologues and 13 paralogues. Broad expression in liver (RPKM 42.6), placenta (RPKM 39.9) and 20 other tissues.

功能概要

该基因编码一种 Kunitz 型丝氨酸蛋白酶抑制剂,可调节组织因子 (TF) 依赖性凝血途径。凝血过程始于因子 VIIa-TF 复合物的形成,该复合物通过蛋白水解激活额外的蛋白酶 (因子 IX 和 X) 并最终导致纤维蛋白凝块的形成。该基因的产物在自动调节环中抑制激活的因子 X 和 VIIa-TF 蛋白酶。抑制编码的蛋白质可以恢复血友病动物模型的止血功能。该基因编码多种蛋白质亚型,这些亚型的抑制活性、特异性和细胞定位各不相同。[RefSeq 提供,2016 年 7 月]

This gene encodes a Kunitz-type Serine Protease Inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

TFPI 基因产物(6)

mRNA Protein Name
NM_001032281.4 NP_001027452.1 tissue factor pathway inhibitor isoform b precursor
NM_001318941.3 NP_001305870.1 tissue factor pathway inhibitor isoform b precursor
NM_001329239.2 NP_001316168.1 tissue factor pathway inhibitor isoform a precursor
NM_001329240.2 NP_001316169.1 tissue factor pathway inhibitor isoform a precursor
NM_001329241.2 NP_001316170.1 tissue factor pathway inhibitor isoform a precursor
NM_006287.6 NP_006278.1 tissue factor pathway inhibitor isoform a precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to steroid hormone stimulus IEP
IEP: 通过表达模式推断
21868574 GOA
involved in negative regulation of blood coagulation IDA
IDA: 通过直接分析推断
21868574 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
21868574 GOA
located in cell surface IDA
IDA: 通过直接分析推断
21868574 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
19065458 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TFPI 蛋白结构

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (53 - 104)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (124 - 175)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (217 - 268)

  • 0
  • 100
  • 200
  • 304 a.a.
蛋白主名 其他名称

tissue factor pathway inhibitor

anti-convertin

重组 TFPI 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77227 TFPI Protein, Human (HEK293, His) P10646/NP_006278.1(D29-K282) ≥95%
HY-P77228 TFPI Protein, Human (Biotinylated, HEK293, His) P10646 (D29-K282) ≥95%
HY-P78212 TFPI Protein, Human (Biotinylated, HEK293, His-Avi) P10646 (D29-K282) ≥95%
HY-P78522 TFPI Protein, Human (HEK293, His-Avi) P10646 (D29-K282) ≥95%

关联疾病

疾病名称 别名
Thrombosis

Thrombosis Of Blood Vessel

Disseminated Intravascular Coagulation

Defibrination Syndrome

Dic

Diffuse Or Disseminated Intravascular Coagulation

Fibrinolytic Purpura

Consumption Coagulopathy

Diffuse Intravascular Coagulation

Dic - [Disseminated Intravascular Coagulation]

Disseminated Intravascular Coagulopathy

Fibrinolysis Nos

Thrombolytic Purpura

Thrombophilia

Hypercoagulability State

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome

Hughes Syndrome

Familial Antiphospholipid Syndrome

Aps

Lupus Anticoagulant, Familial

Anti-Phospholipid Syndrome

Apls

Classic Apls

Classic Antiphospholipid Syndrome

Acromegaloid Facial Appearance Syndrome

Anticardiolipin Syndrome

Carotid Stenosis

Carotid Artery Stenosis

Stenosis, Carotid Artery

Puerperal Pulmonary Embolism

Obstetric Pulmonary Embolism

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Purpura Fulminans

Purpura Gangrenosa

Factor Viii Deficiency

Autosomal Hemophilia A

Hemophilia A

Autosomal Factor Viii Deficiency

Classic Hemophilia A

Congenital Factor Viii Disorder

Subhemophilia

Factor 8 Deficiency, Congenital

Factor Viii

Hemarthrosis

Haemarthrosis Of Shoulder Joint

Haemarthrosis Of The Ankle And Foot

Haemarthrosis Of The Pelvic Region And Thigh

Hemarthrosis Involving Ankle And Foot

Hemarthrosis Involving Forearm

Hemarthrosis Involving Hand

Hemarthrosis Involving Lower Leg

Hemarthrosis Involving Pelvic Region And Thigh

Hemarthrosis Involving Shoulder Region

Hemarthrosis Involving Upper Arm

Hemarthrosis Of Ankle And/Or Foot

Hemarthrosis Of Forearm

Hemarthrosis Of Hand

Hemarthrosis Of Lower Leg

Hemarthrosis Of Shoulder

Hemarthrosis Of Shoulder Region

Hemarthrosis Of The Ankle And Foot

Hemarthrosis Of The Ankle And/Or Foot

Hemarthrosis Of The Forearm

Hemarthrosis Of The Hand

Hemarthrosis Of The Lower Leg

Hemarthrosis Of The Pelvic Region And Thigh

Hemarthrosis Of The Shoulder Region

Hemarthrosis Of The Upper Arm

Hemarthrosis Of Upper Arm

Post-Thrombotic Syndrome

Postphlebitic Syndrome

Postthrombotic Syndrome

Postphlebetic Syndrome With Inflammation

Postphlebetic Syndrome With Ulcer

Postphlebetic Syndrome With Ulcer And Inflammation

Venous Stress Disorder

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency

Rosenthal Syndrome

Pta Deficiency

Hemophilia C

Rosenthal Factor Deficiency

F11 Deficiency

Congenital Factor Xi Deficiency

Hereditary Factor Xi Deficiency Disease

Haemophilia C

Factor Xi Deficiency, Autosomal Dominant

Rosenthal'S Disease

Factor 11 Deficiency

Factor Xi

Factor Xi Deficiency, Autosomal Recessive

Factor Xi Deficiency, Congenital

FA11D

Thromboplastin Antecedent Deficiency

Pta - [Plasma Thromboplastin Antecedent] Deficiency

Congenital Factor Xi Deficiency Disease

Rosenthal Disease

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Hemophilia B

Christmas Disease

Factor Ix Deficiency

F9 Deficiency

HEMB

Plasma Thromboplastin Component Deficiency

Congenital Factor Ix Deficiency

Mild Hemophilia B

Severe Hemophilia B

Congenital Factor Ix Disorder

Deficiency, Functional Factor Ix

Hem B

Mild Congenital F9 Deficiency

Mild Congenital Factor Ix Deficiency

Moderate Hemophilia B

Moderate Congenital F9 Deficiency

Moderate Congenital Factor Ix Deficiency

Severe Congenital F9 Deficiency

Severe Congenital Factor Ix Deficiency

Bleeding Disorder In Hemophilia B Carriers

Congenital F9 Deficiency

Recessive X-Linked Hemophilia B

Blood Coagulation Disease

Blood Coagulation Disorders

Coagulation Protein Disease

Inherited Blood Coagulation Disease

Postpartum Coagulation Defect

Postpartum Coagulation Defect With Delivery

Coagulation Protein Disorders

Puerperal Coagulopathy

Alpha-2-Plasmin Inhibitor Deficiency

Plasmin Inhibitor Deficiency

Antiplasmin Deficiency

Antiplasmin Defiency

Anti-Plasmin Deficiency, Congenital

Antiplasmin Deficiency, Congenital

Congenital Alpha2-Antiplasmin Deficiency

APLID

Congenital Alpha2 Antiplasmin Deficiency

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TFPI RGD RGD:61914
Mus musculus TFPI MGD MGI:1095418
Macaca mulatta TFPI VGNC VGNC:78328
Felis catus TFPI VGNC VGNC:80378
Bos taurus TFPI VGNC VGNC:106975
Canis familiaris TFPI VGNC VGNC:47301
Leporidae TFPI NCBI
Others TFPI NCBI