1. Gene
  2. THRSP - thyroid hormone responsive Gene

THRSP - thyroid hormone responsive Gene

中文名称:甲状腺激素反应

种属: Homo sapiens

同用名: S14; Lpgp; THRP; LPGP1; SPOT14

基因 ID: 7069 | 基因类型: protein coding

关于 THRSP

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:78,063,861-78,068,351 (from NCBI)

This gene has 1 transcript (splice variant), 179 orthologues and 1 paralogue. Biased expression in fat (RPKM 186.6) and liver (RPKM 77.1).

功能概要

该基因编码的蛋白质类似于 S14 的基因产物,S14 是一种大鼠基因,其表达仅限于肝脏和脂肪组织,受营养和激素因素控制。该基因已被证明在肝脏和脂肪细胞中表达,特别是在脂肪瘤模块中。它还被发现在脂肪生成性乳腺癌中表达,这表明它在控制肿瘤脂质代谢中发挥作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

THRSP 基因产物(1)

mRNA Protein Name
NM_003251.4 NP_003242.1 thyroid hormone-inducible hepatic protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

THRSP 蛋白结构

Spot_14

Spot_14: Thyroid hormone-inducible hepatic protein Spot 14 (1 - 143)

  • 0
  • 100
  • 146 a.a.
蛋白主名 其他名称

thyroid hormone-inducible hepatic protein

SPOT14 homolog

THRSP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
THRSP Q92748 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
种属内
THRSP Q92748 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
种属内
THRSP Q92748 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
种属内
THRSP Q92748 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
种属内
THRSP Q92748 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
种属内
THRSP Q92748 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
种属内
THRSP Q92748 TUM1 Saccharomyces cerevisiae Q08686
Y2H Pooling
27107014
种属内
THRSP Q92748 THRSP Homo sapiens Q92748
Y2H Prey Pooling
32296183
种属内
THRSP Q92748 THRSP Homo sapiens Q92748
Y2H Array
25416956
种属内
THRSP Q92748 THRSP Homo sapiens Q92748
Y2H Array
32296183
种属内
THRSP Q92748 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
种属内
THRSP Q92748 TUM1 Saccharomyces cerevisiae Q08686
Validated Y2H
27107014
种属内
THRSP Q92748 THRSP Homo sapiens Q92748
Validated Y2H
32296183
种属内
THRSP Q92748 TUM1 Saccharomyces cerevisiae Q08686
Y2H Array
27107014
种属内
THRSP Q92748 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Canis familiaris THRSP VGNC VGNC:47356
Macaca mulatta THRSP VGNC VGNC:78351
Mus musculus THRSP MGD MGI:109126
Bos taurus THRSP VGNC VGNC:35848
Felis catus THRSP VGNC VGNC:81929
Rattus norvegicus THRSP RGD RGD:3859