2. Gene
  3. KLF10 - KLF transcription factor 10 Gene

KLF10 - KLF transcription factor 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：KLF 转录因子 10

种属: Homo sapiens

同用名: EGRA; TIEG; TIEG1; EGR-alpha

基因 ID: 7071 | 基因类型: protein coding

关于 KLF10

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:102,648,784-102,655,725 (from NCBI)

This gene has 2 transcripts (splice variants), 191 orthologues and 22 paralogues. Ubiquitous expression in bone marrow (RPKM 49.9), gall bladder (RPKM 37.2) and 25 other tissues.

功能概要

该基因编码具有 C2H2 型锌指结构域的蛋白质家族成员。编码的蛋白质是一种转录抑制因子，可作为转化生长因子 β 信号传导的效应子。这种蛋白质的活性可以抑制癌症的生长，尤其是胰腺癌。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 6 月]

This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

KLF10 基因产物(2)

mRNA Protein Name
NM_001032282.4 NP_001027453.1 Krueppel-like factor 10 isoform b
NM_005655.4 NP_005646.1 Krueppel-like factor 10 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
15087465 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15087465 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10976766 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15087465 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLF10 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (385 - 411)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (416 - 438)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
蛋白主名 其他名称

Krueppel-like factor 10

Kruppel like factor 10

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07331 KLF10 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W181026 KLF10-IN-1 / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris KLF10 VGNC VGNC:42431
Bos taurus KLF10 VGNC VGNC:30627
Felis catus KLF10 VGNC VGNC:63130
Mus musculus KLF10 MGD MGI:1101353
Rattus norvegicus KLF10 RGD RGD:621652
Macaca mulatta KLF10 VGNC VGNC:73817
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