TIE1 - tyrosine kinase with immunoglobulin like and EGF like domains 1 Gene

中文名称：具有免疫球蛋白样和 EGF 样结构域的酪氨酸激酶 1

种属: Homo sapiens

同用名: TIE; JTK14; LMPHM11

关于 TIE1

功能概要

该基因编码酪氨酸蛋白激酶家族的一个成员。编码的蛋白质通过内皮受体酪氨酸激酶 Tie2 抑制血管生成素 1 信号，从而在血管生成和血管稳定性中发挥关键作用。编码蛋白的胞外域切割解除了对 Tie2 的抑制，并由包括血管内皮生长因子在内的多种因素介导。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]