2. Gene
  3. TLE3 - TLE family member 3, transcriptional corepressor Gene

TLE3 - TLE family member 3, transcriptional corepressor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TLE 家族成员 3，转录辅阻遏物

种属: Homo sapiens

同用名: ESG; ESG3; GRG3; HsT18976

基因 ID: 7090 | 基因类型: protein coding

关于 TLE3

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:70,047,790-70,097,917 (from NCBI)

This gene has 24 transcripts (splice variants), 271 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues.

功能概要

该基因编码属于转导蛋白样增强子蛋白家族的转录辅抑制蛋白。这个家族的成员在 Notch 信号通路中起作用，该通路调节发育过程中细胞命运的决定。该基因的表达与紫杉烷类化疗对卵巢癌的有利结果相关。交替剪接导致多个转录本变体。已经描述了该基因的其他可变剪接转录变体，但它们的全长性质尚不清楚。[RefSeq 提供，2013 年 9 月]

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

TLE3 基因产物(7)

mRNA Protein Name
NM_001105192.3 NP_001098662.1 transducin-like enhancer protein 3 isoform b
NM_001282979.2 NP_001269908.1 transducin-like enhancer protein 3 isoform e
NM_001282980.2 NP_001269909.1 transducin-like enhancer protein 3 isoform d
NM_001282981.2 NP_001269910.1 transducin-like enhancer protein 3 isoform f
NM_001282982.2 NP_001269911.1 transducin-like enhancer protein 3 isoform g
NM_005078.4 NP_005069.2 transducin-like enhancer protein 3 isoform a
NM_020908.3 NP_065959.1 transducin-like enhancer protein 3 isoform c
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17577209 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of beta-catenin-TCF complex IDA
IDA: 通过直接分析推断
28296634 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
22304967 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TLE3 蛋白结构

TLE_N

TLE_N: Groucho/TLE N-terminal Q-rich domain (1 - 135)

WD40

WD40: WD domain, G-beta repeat (485 - 513)

WD40

WD40: WD domain, G-beta repeat (572 - 604)

WD40

WD40: WD domain, G-beta repeat (610 - 646)

WD40

WD40: WD domain, G-beta repeat (693 - 727)

WD40

WD40: WD domain, G-beta repeat (741 - 768)

  • 0
  • 200
  • 400
  • 600
  • 772 a.a.
蛋白主名 其他名称

transducin-like enhancer protein 3

enhancer of split groucho 3

重组 TLE3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76675 TLE3 Protein, Human (GST) Q04726 (S484-Y772) ≥95%

关联疾病

疾病名称 别名
Chromosome 1q21.1 Duplication Syndrome

1q21.1 Microduplication Syndrome

Trisomy 1q21.1

1q21.1 Duplication Syndrome

1q21.1 Microduplication

1q21.1 Duplication

Dup(1)(Q21.1)
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14565 TLE3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TLE3 MGD MGI:104634
Rattus norvegicus TLE3 RGD RGD:620292
Macaca mulatta TLE3 VGNC VGNC:78366
Felis catus TLE3 VGNC VGNC:66210
Canis familiaris TLE3 VGNC VGNC:47397
Bos taurus TLE3 VGNC VGNC:35891
Others TLE3 NCBI
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