1. Gene
  2. TLR5 - toll like receptor 5 Gene

TLR5 - toll like receptor 5 Gene

中文名称:toll 样受体 5

种属: Homo sapiens

同用名: SLE1; TIL3; SLEB1; MELIOS

基因 ID: 7100 | 基因类型: protein coding

关于 TLR5

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,109,404-223,143,248 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues.

功能概要

该基因编码 toll 样受体 (TLR) 家族的一个成员,该家族在病原体识别和先天免疫反应的激活中起着重要作用。这些受体识别在感染因子上表达的不同病原体相关分子模式。由该基因编码的蛋白质识别细菌鞭毛蛋白,细菌鞭毛的主要成分和毒力因子。该受体的激活动员了核因子 NF-kappaB,后者又激活了许多与炎症相关的靶基因。该基因的突变与对系统性红斑狼疮的抵抗力和易感性以及对军团病的易感性有关。[RefSeq 提供,2009 年 12 月]

This gene encodes a member of the Toll-like Receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes Bacterial flagellin, the principal component of Bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

TLR5 基因产物(1)

mRNA Protein Name
NM_003268.6 NP_003259.2 toll-like receptor 5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-1 receptor binding IPI
IPI: 通过物理相互作用推断
12925853 GOA
enables pattern recognition receptor activity IDA
IDA: 通过直接分析推断
14625549 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30158114 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
acts upstream of positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
17128265 GOA
involved in toll-like receptor 5 signaling pathway IDA
IDA: 通过直接分析推断
14625549 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
24778236 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TLR5 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (49 - 107)

LRR_8

LRR_8: Leucine rich repeat (135 - 182)

LRR_8

LRR_8: Leucine rich repeat (314 - 372)

LRR_1

LRR_1: Leucine Rich Repeat (385 - 401)

LRR_8

LRR_8: Leucine rich repeat (491 - 538)

TIR

TIR: TIR domain (695 - 834)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 858 a.a.
蛋白主名 其他名称

toll-like receptor 5

systemic lupus erythematosus susceptibility 1

关联疾病

疾病名称 别名
Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia

Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease

Systemic Lupus Erythematosus 1

SLEB1

Systemic Lupus Erythematosus, Susceptibility To, 1

Systemic Lupus Erythematosus, Resistance To

Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic, Type 1

Lupus Erythematosus, Systemic

Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Typhoid Fever

Typhoid

Enteric Fever

Typhoidal Salmonellosis

Ileotyphus

Infection By Salmonella Typhi

Typhoid Any Site

Typhoid Fever Any Site

Typhoid Infection

Typhoid Infection Any Site

Typhoid Fever Confirmed

Enteric Fever Nos

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Bacteriuria
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Ileitis

Crohn'S Ileitis

Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection

Colitis
Toxoplasmosis

Disseminated Toxoplasmosis

Multisystemic Disseminated Toxoplasmosis

Acquired Toxoplasmosis

Toxoplasmosis Disease Or Disorder

Infection By Toxoplasma Gondii

Toxoplasmal

Toxoplasma

Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Salmonellosis

Salmonella Infections

Salmonella Infection

Otitis Media

Opsoclonus-Myoclonus Syndrome

OMS

Otitis Media, Susceptibility To

Kinsbourne Syndrome

Otitis Media, Chronic/Recurrent

Come/Rom

Ataxo-Opso-Myoclonus Syndrome

Dancing Eye Syndrome

Dancing Eye-Dancing Feet Syndrome

Oma Syndrome

Opsoclonus Myoclonus Syndrome

Opsoclonus-Myoclonus-Ataxia Syndrome

Poma Syndrome

Paraneoplastic Opsoclonus-Myoclonus

Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome

Opsoclonus Myoclonus

OM

{Otitis Media, Susceptibility To}

Infectious Otitis Media

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma

Von Willebrand Disease, Type 3

Von Willebrand Disease Type 3

VWD3

Von Willebrand'S Disease 3

Von Willebrand Disease Type Iii

Von Willebrand Disease, Type Iii

Vwd, Type 3

Vwd Type 3

Von Willebrand Disease 3

Von Willebrand Disease Recessive Form

Von Willebrand Factor Deficiency Type 3

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Chromosome 17q23.1-Q23.2 Deletion Syndrome

17q23.1q23.2 Microdeletion Syndrome

17q23.1-Q23.2 Microdeletion Syndrome

Del(17)(Q23.1q23.2)

Monosomy 17q23.1q23.2

Monosomy 17q23.1-Q23.2

Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos

Pneumonic Tularemia

Pulmonary Tularemia

Bronchopneumonic Tularemia

Pneumonic Tularaemia

Glanders

Farcy Pipes

Infection Due To Pseudomonas Mallei

Burkholderia Mallei

Burkholderia Mallei Infection

Equina

Equine Glanders

Farcy

Farcy Buds

Farcy Cords

Infection Due To Actinobacillus Mallei

Infection Due To Malleomyces Mallei

Maliasmus

Malleus

Farce

Actinobacillosis

Actinobacillus Infection

Primary Bacterial Infectious Disease
Anogenital Venereal Wart

Genital Warts

Condylomata Acuminata

Anogenital Warts

Condyloma Acuminatum

Anogenital Human Papilloma Virus Infectious Disease

Genital Wart Virus Infectious Disease

Venereal Wart

Venereal Warts

Verrucae Anogenitales

Verrucae Genitales

Blood Group, Globoside System

Globe Disease

GLOB

Blood Group System, Globoside

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis

Enterocolitis Necrotizing

Enterocolitis, Necrotizing

Necrotizing Enterocolitis In Fetus Or Newborn

Perinatal Necrotising Enterocolitis

Pseudomembranous Enterocolitis In Newborn

Nec

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Plague

Yersiniosis

Yersinia Infections

Infection By Yersinia Pestis

Pasteurella Pestis Infection

Pestilential Fever

Yersinia Pestis Infection

Cataract 9, Multiple Types

Cataract 9 Multiple Types

CTRCT9

Cataract, Autosomal Dominant

Catc1

Cataract 9, Multiple Types, With Or Without Microcornea

Cataract, Autosomal Recessive Congenital 1

Autosomal Recessive Congenital Cataract 1

Cataract 9 Multiple Types With Or Without Microcornea

Autosomal Dominant Congenital Cataract

Cataract Autosomal Dominant

Cataracts, Autosomal Dominant

Ankylosing Spondylitis 1

Ankylosing Spondylitis, Susceptibility To, 1

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TLR5 RGD RGD:631351
Bos taurus TLR5 VGNC VGNC:52835
Mus musculus TLR5 MGD MGI:1858171
Macaca mulatta TLR5 VGNC VGNC:78376
Felis catus TLR5 VGNC VGNC:107950