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  3. NR2E1 - nuclear receptor subfamily 2 group E member 1 Gene

NR2E1 - nuclear receptor subfamily 2 group E member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体亚家族 2 E 组成员 1

种属: Homo sapiens

同用名: TLL; TLX; XTLL

基因 ID: 7101 | 基因类型: protein coding

关于 NR2E1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:108,166,022-108,188,809 (from NCBI)

This gene has 4 transcripts (splice variants), 230 orthologues and 11 paralogues. Restricted expression toward brain (RPKM 4.0).

功能概要

该基因编码的蛋白质是一种参与视网膜发育的孤儿受体。编码的蛋白质还调节成人神经干细胞增殖，并可能参与攻击行为的控制。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2015 年 8 月]

The protein encoded by this gene is an Orphan Receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

NR2E1 基因产物(2)

mRNA Protein Name
NM_001286102.1 NP_001273031.1 nuclear receptor subfamily 2 group E member 1 isoform a
NM_003269.5 NP_003260.1 nuclear receptor subfamily 2 group E member 1 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28420882 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NR2E1 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (15 - 85)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (182 - 366)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
蛋白主名 其他名称

nuclear receptor subfamily 2 group E member 1

nuclear receptor TLX

NR2E1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NR2E1 Q9Y466 KDM1A Homo sapiens O60341
Anti Tag CoIP
36321378
种属内
NR2E1 Q9Y466 KDM1A Homo sapiens O60341
PLA
28420882
种属内
NR2E1 Q9Y466 KDM1A Homo sapiens O60341
H1-H2 MS
36321378
种属内
NR2E1 Q9Y466 KDM1A Homo sapiens O60341
Anti Bait CoIP
28420882
种属间: 跨种属相互作用 种属内: 同种属相互作用

NR2E1 抗体

目录号 产品名 应用 反应物种
HY-P82903 NR2E1 Antibody (YA2648) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Enhanced S-Cone Syndrome

Goldmann-Favre Syndrome

ESCS

Favre Hyaloideoretinal Degeneration

Retinoschisis With Early Hemeralopia

Retinoschisis With Early Nyctalopia

Enhanced S Cone Syndrome

S-Cone Syndrome, Enhanced
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135572 TLX agonist 1 Modulator 99.94% 否
HY-RS09539 NR2E1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NR2E1 VGNC VGNC:68550
Bos taurus NR2E1 VGNC VGNC:32238
Macaca mulatta NR2E1 VGNC VGNC:75510
Canis familiaris NR2E1 VGNC VGNC:43949
Mus musculus NR2E1 MGD MGI:1100526
Rattus norvegicus NR2E1 RGD RGD:1595162
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