TNFAIP6 - TNF alpha induced protein 6 Gene

中文名称：肿瘤坏死因子α诱导蛋白 6

种属: Homo sapiens

同用名: TSG6; TSG-6

关于 TNFAIP6

功能概要

由该基因编码的蛋白质是一种含有透明质酸结合结构域的分泌蛋白，因此是透明质酸结合蛋白家族的成员。已知乙酰透明质酸结合域参与细胞外基质稳定性和细胞迁移。这种蛋白质已显示与 inter-alpha 抑制剂 (I alpha I) 形成稳定的复合物，从而增强 I alpha I 的丝氨酸蛋白酶抑制活性，这在与炎症相关的蛋白酶网络中很重要。该基因可由促炎细胞因子如肿瘤坏死因子α和白细胞介素-1 诱导。在骨关节炎和类风湿性关节炎患者的滑液中发现这种蛋白质水平升高。[RefSeq 提供，2010 年 12 月]

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]