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  2. TNS1 - tensin 1 Gene

TNS1 - tensin 1 Gene

中文名称:张力蛋白 1

种属: Homo sapiens

同用名: TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155

基因 ID: 7145 | 基因类型: protein coding

关于 TNS1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:217,799,791-218,033,982 (from NCBI)

This gene has 24 transcripts (splice variants), 222 orthologues and 6 paralogues. Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues.

功能概要

由该基因编码的蛋白质定位于粘着斑,即细胞附着于细胞外基质的质膜区域。这种蛋白质交联肌动蛋白丝并包含一个 Src 同源 2 (SH2) 结构域,该结构域通常存在于参与信号转导的分子中。这种蛋白质是钙蛋白酶 II 的底物。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2015 年 4 月]

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

TNS1 基因产物(4)

mRNA Protein Name
NM_001308022.2 NP_001294951.1 tensin-1 isoform 2
NM_001308023.2 NP_001294952.1 tensin-1 isoform 3
NM_001387777.1 NP_001374706.1 tensin-1 isoform 4
NM_022648.7 NP_072174.3 tensin-1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17190795 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in focal adhesion IDA
IDA: 通过直接分析推断
11023826 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TNS1 蛋白结构

PTEN_C2

PTEN_C2: C2 domain of PTEN tumour-suppressor protein (179 - 305)

SH2

SH2: SH2 domain (1463 - 1557)

PTB

PTB: Phosphotyrosine-binding domain (1598 - 1734)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1735 a.a.
蛋白主名 其他名称

tensin-1

Matrix-remodelling-associated protein 6

TNS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TNS1 Q9HBL0 MET Homo sapiens P08581
FPS
24728074
种属内
TNS1 Q9HBL0 KIT Homo sapiens P10721
FPS
24728074
种属内
TNS1 Q9HBL0 AR Homo sapiens P10275
FPS
24728074
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastric Fundus Cancer

Gastric Fundus Carcinoma

Ca Fundus - Stomach

Malignant Neoplasm Of Fundus Of Stomach

Malignant Tumor Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Carcinoma Of Fundus Of Stomach

Malignant Neoplasm Of Gastric Fundus

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome

Pten Hamartoma Tumor Syndrome

Lhermitte-Duclos Disease

Bannayan-Zonana Syndrome

Phts

Riley-Smith Syndrome

Bzs

Ruvalcaba-Myhre-Smith Syndrome

Multiple Hamartoma Syndrome

Rmss

Brrs

Dysplastic Gangliocytoma Of The Cerebellum

CWS1

Cs

Cd

Mham

Pten Hamartoma Tumor Syndrome With Granular Cell Tumor

Macrocephaly Multiple Lipomas And Hemangiomata

Bannayan-Ruvalcaba-Riley Syndrome

Myhre-Riley-Smith Syndrome

LDD

Cerebelloparenchymal Disorder Vi

Hamartoma Syndrome, Multiple

Bbrs

Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata

Macrocephaly, Multiple Lipomas, And Hemangiomata

Macrocephaly Pseudopapilledema And Multiple Hemangiomas

Ruvalcaba -Myhre-Smith Syndrome

Ruvalcaba-Myhre Syndrome

Cowden Disease

Macrocephaly Pseudopapilledema And Multiple Hemangiomata

Cerebellar Granule Cell Hypertrophy And Megalencephaly

Cpd6

Pten Hamartoma Tumor Syndromes

Cowden Syndrome, Type 1

Orthostatic Intolerance

Mitral Valve Prolapse

Neurocirculatory Asthenia

Mitral Valve Prolapse Syndrome

Irritable Heart

Systolic Click-Murmur Syndrome

Soldiers Heart

Cardiovascular Malfunction Arising From Mental Factors

Cardiovascular Neurosis

Da Costa'S Syndrome

Krishaber'S Disease

Barlow'S Syndrome

Floppy Mitral Valve

Mitral Leaflet Syndrome

Myxomatous Mitral Valve Prolapse

Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency

Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency

Orthostatic Intolerance Due To Net Deficiency

Pots Due To Net Deficiency

OI

Intolerance, Orthostatic

Mitral Valve Prolapse, Familial, X-Linked

Ballooning Mitral Valve

Barlow Syndrome

Flail Mitral Leaflet

Myxomatous Mitral Valve

Mitral Valve Prolapse-Click Syndrome

Prolapsing Mitral Valve Leaflet Syndrome

Billowing Mitral Valve Leaflet

Posterior Mitral Leaflet Deformity

Ballooning Posterior Leaflet Syndrome

Blue Valve Syndrome

Floppy Mitral Valve Syndrome

Mitral Valvular Prolapse

Systolic Click Syndrome

Cowden Syndrome

Cowden Disease

Multiple Hamartoma Syndrome

Cowden'S Disease

Lhermitte-Duclos Disease

Cd

Cs

Mham

Dysplastic Gangliocytoma Of Cerebellum

Cowden'S Syndrome

Hamartoma Syndrome, Multiple

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNS1 RGD RGD:68427
Mus musculus TNS1 MGD MGI:104552
Macaca mulatta TNS1 VGNC VGNC:78414
Canis familiaris TNS1 VGNC VGNC:47701
Felis catus TNS1 VGNC VGNC:66435
Bos taurus TNS1 VGNC VGNC:36207