TPD52L2 - TPD52 like 2 Gene

中文名称：TPD52 样 2

种属: Homo sapiens

同用名: D54; TPD54

基因 ID: 7165 | 基因类型: protein coding

关于 TPD52L2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,865,270-63,891,538 (from NCBI)

This gene has 10 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 35.6), bone marrow (RPKM 34.4) and 25 other tissues.

功能概要

该基因编码肿瘤蛋白 D52 样家族的一个成员。这些蛋白质的特征在于 N 末端卷曲螺旋基序，该基序用于与其他肿瘤蛋白 D52 样蛋白形成同聚和异聚复合物。该基因的表达可能是乳腺癌和急性淋巴细胞白血病的标志物。已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因位于 12 号染色体的长臂上。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with Other tumor protein D52-like proteins. Expression of this gene may be a marker for breast Cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

TPD52L2 基因产物(10)

mRNA	Protein	Name
NM_001243891.2	NP_001230820.1	tumor protein D54 isoform g
NM_001243892.2	NP_001230821.1	tumor protein D54 isoform h
NM_001243894.2	NP_001230823.1	tumor protein D54 isoform i
NM_001243895.2	NP_001230824.1	tumor protein D54 isoform j
NM_003288.4	NP_003279.2	tumor protein D54 isoform e
NM_199359.3	NP_955391.1	tumor protein D54 isoform f
NM_199360.3	NP_955392.1	tumor protein D54 isoform a
NM_199361.3	NP_955393.1	tumor protein D54 isoform b
NM_199362.3	NP_955394.1	tumor protein D54 isoform c
NM_199363.3	NP_955395.1	tumor protein D54 isoform d

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9484778	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	9484778	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16112108	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	16112108	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPD52L2 蛋白结构

TPD52

0
100
206 a.a.

蛋白主名

其他名称

tumor protein D54

HCCR-binding protein 2

TPD52L2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TPD52L2	O43399	SH3GLB1	Homo sapiens	Q9Y371	Validated Y2H	32296183
种属内	TPD52L2	O43399	ABHD5	Homo sapiens	Q8WTS1	Validated Y2H	32296183
种属内	TPD52L2	O43399	ABHD5	Homo sapiens	Q8WTS1	Y2H Prey Pooling	32296183
种属内	TPD52L2	O43399	ABHD5	Homo sapiens	Q8WTS1	Y2H Array	32296183
种属内	TPD52L2	O43399	COQ8A	Homo sapiens	Q8NI60	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14930	TPD52L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	TPD52L2	VGNC	VGNC:47735
Rattus norvegicus	TPD52L2	RGD	RGD:735167
Bos taurus	TPD52L2	VGNC	VGNC:36246
Macaca mulatta	TPD52L2	VGNC	VGNC:98462
Mus musculus	TPD52L2	MGD	MGI:1913564
Felis catus	TPD52L2	VGNC	VGNC:66472

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TPD52L2 - TPD52 like 2 Gene

关于 TPD52L2

功能概要

TPD52L2 基因产物(10)

TPD52L2 蛋白结构

TPD52L2 蛋白互作信息

关联疾病

直系同源

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TPD52L2 - TPD52 like 2 Gene

关于 TPD52L2

功能概要

TPD52L2 基因产物(10)

TPD52L2 蛋白结构

TPD52L2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z