2. Gene
  3. TPD52L2 - TPD52 like 2 Gene

TPD52L2 - TPD52 like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TPD52 样 2

种属: Homo sapiens

同用名: D54; TPD54

基因 ID: 7165 | 基因类型: protein coding

关于 TPD52L2

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,865,270-63,891,538 (from NCBI)

This gene has 10 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 35.6), bone marrow (RPKM 34.4) and 25 other tissues.

功能概要

该基因编码肿瘤蛋白 D52 样家族的一个成员。这些蛋白质的特征在于 N 末端卷曲螺旋基序，该基序用于与其他肿瘤蛋白 D52 样蛋白形成同聚和异聚复合物。该基因的表达可能是乳腺癌和急性淋巴细胞白血病的标志物。已观察到该基因编码多种亚型的选择性剪接转录变体，该基因的假基因位于 12 号染色体的长臂上。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast Cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]

TPD52L2 基因产物(10)

mRNA Protein Name
NM_001243891.2 NP_001230820.1 tumor protein D54 isoform g
NM_001243892.2 NP_001230821.1 tumor protein D54 isoform h
NM_001243894.2 NP_001230823.1 tumor protein D54 isoform i
NM_001243895.2 NP_001230824.1 tumor protein D54 isoform j
NM_003288.4 NP_003279.2 tumor protein D54 isoform e
NM_199359.3 NP_955391.1 tumor protein D54 isoform f
NM_199360.3 NP_955392.1 tumor protein D54 isoform a
NM_199361.3 NP_955393.1 tumor protein D54 isoform b
NM_199362.3 NP_955394.1 tumor protein D54 isoform c
NM_199363.3 NP_955395.1 tumor protein D54 isoform d
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9484778 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9484778 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16112108 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16112108 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPD52L2 蛋白结构

TPD52

TPD52: Tumour protein D52 family (34 - 198)

  • 0
  • 100
  • 206 a.a.
蛋白主名 其他名称

tumor protein D54

HCCR-binding protein 2

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14930 TPD52L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TPD52L2 VGNC VGNC:47735
Rattus norvegicus TPD52L2 RGD RGD:735167
Bos taurus TPD52L2 VGNC VGNC:36246
Macaca mulatta TPD52L2 VGNC VGNC:98462
Mus musculus TPD52L2 MGD MGI:1913564
Felis catus TPD52L2 VGNC VGNC:66472
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z