2. Gene
  3. HSP90B1 - heat shock protein 90 beta family member 1 Gene

HSP90B1 - heat shock protein 90 beta family member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热休克蛋白 90 β 家族成员 1

种属: Homo sapiens

同用名: ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m

基因 ID: 7184 | 基因类型: protein coding

关于 HSP90B1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,930,410-103,947,926 (from NCBI)

This gene has 35 transcripts (splice variants), 224 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 807.9), appendix (RPKM 260.4) and 24 other tissues.

功能概要

该基因编码三磷酸腺苷 (ATP) 代谢分子伴侣家族的一个成员，其在稳定和折叠其他蛋白质方面发挥作用。编码的蛋白质定位于黑素体和内质网。这种蛋白质的表达与多种致病状态有关，包括肿瘤形成。该基因的 5' 外显子内有一个 MicroRNA 基因。该基因在 1 号和 15 号染色体上存在假基因。[RefSeq 提供，2012 年 8 月]

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding Other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a MicroRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

HSP90B1 基因产物(1)

mRNA Protein Name
NM_003299.3 NP_003290.1 endoplasmin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
11958450 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9596688 GOA
enables protein phosphatase binding IDA
IDA: 通过直接分析推断
19000834 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IMP
IMP: 通过突变表型推断
18264092 GOA
acts upstream of or within actin rod assembly IDA
IDA: 通过直接分析推断
19000834 GOA
acts upstream of or within cellular response to ATP IDA
IDA: 通过直接分析推断
19000834 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
10497210 GOA
involved in response to hypoxia IDA
IDA: 通过直接分析推断
15620698 GOA
involved in retrograde protein transport, ER to cytosol IMP
IMP: 通过突变表型推断
25660456 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
9596688 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
17344063 GOA
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
10497210 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
10497210 GOA
located in midbody IDA
IDA: 通过直接分析推断
15166316 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10497210 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23349634 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSP90B1 蛋白结构

HATPase_c_3

HATPase_c_3: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (95 - 229)

HSP90

HSP90: Hsp90 protein (257 - 783)

  • 0
  • 200
  • 400
  • 600
  • 803 a.a.
蛋白主名 其他名称

endoplasmin

94 kDa glucose-regulated protein

HSP90B1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSP90B1 P14625 HSPA5 Homo sapiens P11021
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

HSP90B1 抗体

目录号 产品名 应用 反应物种
HY-P82774 GRP94 Antibody (YA2519) WB, IHC-P, ICC/IF Human, Mouse

关联疾病

疾病名称 别名
Pelizaeus-Merzbacher-Like Disease

Pmld
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T

PLSDT

Platyspondylic Dysplasia, Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

Thanatophoric Dysplasia, Torrance Variant

Platyspondylic Skeletal Dysplasia, Torrance Type

Torrance Type Platyspondylic Dysplasia

Platyspondylic Dysplasia, Torrance-Luton Type

Platyspondylic Lethal Skeletal Dysplasia Torrance Type

Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

Thanatophoric Dysplasia Torrance Variant

Platyspondylic Chondrodysplasia, Torrance-Luton Type

Plsd-Tl

Dysplasia, Skeletal, Platyspondylic, Torrance Type
Pseudoachondroplasia

PSACH

Pseudoachondroplastic Dysplasia

Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome

Spondyloepiphyseal Dysplasia, Pseudoachondroplastic

Pseudoachondroplastic Spondyloepiphyseal Dysplasia

Spondyloepiphyseal Dysplasia Pseudoachondroplastic
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10214 SNX-2112 99.49% 否
HY-RS06419 HSP90B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HSP90B1 MGD MGI:98817
Felis catus HSP90B1 VGNC VGNC:84033
Bos taurus HSP90B1 VGNC VGNC:49984
Rattus norvegicus HSP90B1 RGD RGD:1310482
Macaca mulatta HSP90B1 VGNC VGNC:97776
Canis familiaris HSP90B1 VGNC VGNC:54212
Others HSP90B1 NCBI
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