C4BPA - complement component 4 binding protein alpha Gene

中文名称：补体成分 4 结合蛋白 α

种属: Homo sapiens

同用名: PRP; C4BP

关于 C4BPA

功能概要

该基因编码的蛋白质超家族成员主要由大约 60 个氨基酸的串联排列的短共有重复序列组成。与一条独特的 β 链一起，由该基因编码的 7 条相同的 α 链组装成 C4b 结合蛋白的主要亚型，这是一种通过经典途径控制补体级联激活的多聚体蛋白。编码 α 和 β 链的基因在补体激活基因簇的调节因子中位于人类 1 号染色体上彼此相邻。该基因簇中还发现了该基因的两个假基因。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 Amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each Other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]