2. Gene
  3. Rps6kb1 - ribosomal protein S6 kinase, polypeptide 1 Gene

Rps6kb1 - ribosomal protein S6 kinase, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶，多肽 1

种属: Mus musculus

同用名: S6K; S6K1; p70s6k; P70S6K1; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha

基因 ID: 72508 | 基因类型: protein coding

关于 Rps6kb1

Chromosome 11: 86,389,697-86,435,631 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 155 orthologues, 7 paralogues and is associated with 25 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 5.), limb E14.5 (RPKM 4.8) and 26 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶活性。参与多个过程，包括细胞对干扰素-γ 的反应；长链脂肪酸导入细胞；和肽基丝氨酸磷酸化。在多个流程的上游或内部采取行动，包括行为恐惧反应；细胞对激素刺激的反应；和蛋白激酶 B 信号。位于线粒体中。以多种结构表达，包括中枢神经系统；早孕;嗅觉上皮；生殖系统;和视网膜核层。与人 RPS6KB1（核糖体蛋白 S6 激酶 B1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Involved in several processes, including cellular response to interferon-gamma; long-chain fatty acid import into cell; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including behavioral fear response; cellular response to hormone stimulus; and protein kinase B signaling. Located in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; olfactory epithelium; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb1 基因产物(3)

mRNA Protein Name
NM_001363162.1 NP_001350091.1 ribosomal protein S6 kinase beta-1 isoform 3
NM_028259.4 NP_082535.1 ribosomal protein S6 kinase beta-1 isoform 2
NM_001114334.2 NP_001107806.1 ribosomal protein S6 kinase beta-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20657550 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
15249583 MGI
enables protein kinase activity IMP
IMP: 通过突变表型推断
15249583 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within behavioral fear response IGI
IGI: 通过遗传相互作用推断
24990923 MGI
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: 通过直接分析推断
17556672 MGI
acts upstream of or within cellular response to insulin stimulus IGI
IGI: 通过遗传相互作用推断
24349514 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
24990923 MGI
involved in cellular response to type II interferon IMP
IMP: 通过突变表型推断
28178239 MGI
acts upstream of or within germ cell development IDA
IDA: 通过直接分析推断
12140361 MGI
involved in long-chain fatty acid import into cell IMP
IMP: 通过突变表型推断
28178239 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
18174371 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
18174371 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
11493700 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
11493700 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
15249583 MGI
involved in peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
28178239 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
15249583 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
15249583 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18174371 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
18174371 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
11493700 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rps6kb1 蛋白结构

STKc_p70S6K

STKc_p70S6K: cd05584 (93 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 525 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase beta-1

70 kDa ribosomal protein S6 kinase 1

p70 S6 kinase alpha

p70 ribosomal S6 kinase alpha

ribosomal protein S6 kinase I

ribosomal protein S6 kinase, 70kD, polypeptide 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148062 RSS0680 98.03% 否
HY-RS12262 RPS6KB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12263 Rps6kb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12264 Rps6kb1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rps6kb1 NCBI NCBI:6198
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