1. Gene
  2. Adipor1 - adiponectin receptor 1 Gene

Adipor1 - adiponectin receptor 1 Gene

种属: Mus musculus

同用名: Paqr1; ACDCR1; CGI-45; 2810031L11Rik

基因 ID: 72674 | 基因类型: protein coding

关于 Adipor1

功能概要

This gene encodes a receptor for the fat-derived hormone Adiponectin. Binding of Adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and Insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and Insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Adipor1 基因产物(2)

mRNA Protein Name
NM_001306069.1 NP_001292998.1 adiponectin receptor protein 1
NM_028320.4 NP_082596.2 adiponectin receptor protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adiponectin binding IPI
IPI: 通过物理相互作用推断
12802337 MGI
enables identical protein binding IDA
IDA: 通过直接分析推断
12802337 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12802337 MGI
enables signaling receptor activity IDA
IDA: 通过直接分析推断
12802337 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adiponectin-activated signaling pathway IDA
IDA: 通过直接分析推断
12802337 MGI
involved in adiponectin-activated signaling pathway IMP
IMP: 通过突变表型推断
24742672 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
24742672 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
24531262 MGI
involved in regulation of glucose metabolic process IMP
IMP: 通过突变表型推断
24742672 MGI
involved in regulation of lipid metabolic process IMP
IMP: 通过突变表型推断
24742672 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
12802337 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

adiponectin receptor protein 1

progestin and adipoQ receptor family member 1

progestin and adipoQ receptor family member I

Adipor1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Adipor1 Q91VH1 APPL1 Homo sapiens Q9UKG1
Y2H
16622416
种属间
Adipor1 Q91VH1 APPL1 Homo sapiens Q9UKG1
Pull Down
16622416
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adipor1 NCBI NCBI:51094