2. Gene
  3. CDK11A - cyclin dependent kinase 11A Gene

CDK11A - cyclin dependent kinase 11A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 11A

种属: Homo sapiens

同用名: CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110

基因 ID: 728642 | 基因类型: protein coding

关于 CDK11A

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,702,379-1,724,357 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and 26 paralogues. Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶家族的成员。已知该激酶家族的成员对真核细胞周期控制至关重要。由于片段重复，该基因与邻近基因具有非常高的序列同一性。这两个基因在神经母细胞瘤中经常被删除或改变。该基因编码的蛋白激酶可被半胱天冬酶切割，并可能在细胞凋亡中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 9 月]

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

CDK11A 基因产物(4)

mRNA Protein Name
NM_001313896.2 NP_001300825.1 cyclin-dependent kinase 11A isoform 5
NM_001313982.2 NP_001300911.1 cyclin-dependent kinase 11A isoform 3
NM_024011.4 NP_076916.2 cyclin-dependent kinase 11A isoform 1
NM_033529.4 NP_277071.2 cyclin-dependent kinase 11A isoform 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12501247 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12501247 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12501247 GOA
involved in regulation of RNA splicing IDA
IDA: 通过直接分析推断
12501247 GOA
involved in regulation of cell growth IEP
IEP: 通过表达模式推断
10882096 GOA
involved in regulation of mRNA processing IDA
IDA: 通过直接分析推断
12501247 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: 通过物理相互作用推断
18216018 GOA
located in nucleus IDA
IDA: 通过直接分析推断
8195233 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDK11A 蛋白结构

Pkinase

Pkinase: Protein kinase domain (426 - 711)

  • 0
  • 200
  • 400
  • 600
  • 783 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 11A

PITSLRE B

CDK11A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDK11A Q9UQ88 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood Endodermal Sinus Tumor

Childhood Endodermal Sinus Neoplasm

Childhood Endodermal Sinus Tumour

Paediatric Yolk Sac Tumour

Pediatric Yolk Sac Tumor

Childhood Yolk Sac Tumor
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-155874 ZNL-05-044 Inhibitor 99.91% 否
HY-RS02352 CDK11A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CDK11A MGD MGI:88353
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