UBTF - upstream binding transcription factor Gene

中文名称：上游结合转录因子

种属: Homo sapiens

同用名: UBF; UBF1; UBF2; UBF-1; CONDBA; NOR-90

基因 ID: 7343 | 基因类型: protein coding

关于 UBTF

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,205,040-44,221,304 (from NCBI)

This gene has 18 transcripts (splice variants), 202 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 22.2), thyroid (RPKM 21.0) and 25 other tissues.

功能概要

该基因编码 HMG-box DNA 结合蛋白家族的成员。编码的蛋白质在核糖体 RNA 转录中起着关键作用，作为预启动复合物的关键成分，介导 RNA 聚合酶 I 募集到 rDNA 启动子区域。编码的蛋白质也可能在染色质重塑和前 rRNA 加工中发挥重要作用，其活性受磷酸化和乙酰化的调节。已经观察到该基因编码多种亚型的可变剪接转录物变体。该基因的假基因位于 3 号、11 号和 X 号染色体的短臂以及 11 号染色体的长臂上。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

UBTF 基因产物(3)

mRNA	Protein	Name
NM_001076683.2	NP_001070151.1	nucleolar transcription factor 1 isoform b
NM_001076684.3	NP_001070152.1	nucleolar transcription factor 1 isoform b
NM_014233.4	NP_055048.1	nucleolar transcription factor 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase I cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	22368283	GOA
enables RNA polymerase I core promoter sequence-specific DNA binding	IDA IDA: 通过直接分析推断	22368283	GOA
enables RNA polymerase I general transcription initiation factor activity	IDA IDA: 通过直接分析推断	12498690	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	26089203	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12498690	GOA
enables scaffold protein binding	IPI IPI: 通过物理相互作用推断	23203802	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in regulation of glucose mediated signaling pathway	IDA IDA: 通过直接分析推断	22368283	GOA
involved in transcription by RNA polymerase I	IMP IMP: 通过突变表型推断	28777933	GOA
involved in transcription initiation at RNA polymerase I promoter	IDA IDA: 通过直接分析推断	12498690	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleolus	IDA IDA: 通过直接分析推断	12498690	GOA
located in nucleus	IDA IDA: 通过直接分析推断	22368283	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBTF 蛋白结构

HMG_box

HMG_box_2

HMG_box

HMG_box_5

0
200
400
600
764 a.a.

蛋白主名

其他名称

nucleolar transcription factor 1

90-kDa nucleolus organizer region autoantigen

UBTF 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UBTF	P17480	SET	Homo sapiens	Q01105	Pull Down	17318177
种属内	UBTF	P17480	SET	Homo sapiens	Q01105	Anti Tag CoIP	17318177
种属内	UBTF	P17480	RUNX2	Homo sapiens	Q13950	Anti Bait CoIP	20160071
种属内	UBTF	P17480	RUNX2	Homo sapiens	Q13950	Anti Bait CoIP	17251981

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBTF 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72282	Nucleolar transcription factor 1/UBTF Protein, Human (His-SUMO)	P17480 (M1-T670)	≥95%

关联疾病

疾病名称

别名

Neurodegeneration, Childhood-Onset, With Brain Atrophy

Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder	CONDBA
Childhood-Onset Neurodegeneration With Brain Atrophy

Rare Syndromic Intellectual Disability

Warsaw Breakage Syndrome

WABS

WBRS

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Muscle Hypertrophy

MSLHP	Hypertrophy
Hypertrophy, Muscle

Cerebrooculofacioskeletal Syndrome 4

COFS4	Cerebro-Oculo-Facio-Skeletal Syndrome 4
Cofs Syndrome	Cerebrooculofacioskeletal Syndrome, Type 4

Anemia, Congenital Dyserythropoietic, Type Ia

Congenital Dyserythropoietic Anemia Type I	Cda I
CDAN1A	Congenital Dyserythropoietic Anemia Type 1
Congenital Dyserythropoietic Anemia Type Ia	Congenital Dyserythropoietic Anemia, Type I
Anemia, Congenital Dyserythropoietic, Type I	Cda Type 1
Cda Type I	Cda Ia
Dyserythropoietic Anemia, Congenital Type 1	Anemia, Congenital Dyserythropoietic, Type 1a
Dyserythropoietic Anemia, Congenital, Type Ia	Cda, Type Ia
Congenital Dyserythropoietic Anaemia Type 1	Congenital Dyserythropoietic Anaemia Type I
Anemia, Dyserythropoietic, Congenital Type 1	Type I Congenital Dyserythropoietic Anemia
Anemia, Congenital Dyserythropoietic, 1a	Anemia, Dyserythropoietic, Congenital, Type Ia

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Retinitis Pigmentosa 11

RP11	Retinitis Pigmentosa-11
Retinitis Pigmentosa, Type 11

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15393	UBTF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	UBTF	VGNC	VGNC:108188
Felis catus	UBTF	VGNC	VGNC:108189
Canis familiaris	UBTF	VGNC	VGNC:108184
Rattus norvegicus	UBTF	RGD	RGD:3927
Mus musculus	UBTF	MGD	MGI:98512
Macaca mulatta	UBTF	VGNC	VGNC:108187
Others	UBTF	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UBTF - upstream binding transcription factor Gene

关于 UBTF

功能概要

UBTF 基因产物(3)

UBTF 蛋白结构

UBTF 蛋白互作信息

重组 UBTF 蛋白

关联疾病

直系同源

热门区域

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UBTF - upstream binding transcription factor Gene

关于 UBTF

功能概要

UBTF 基因产物(3)

UBTF 蛋白结构

UBTF 蛋白互作信息

重组 UBTF 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z