2. Gene
  3. USP1 - ubiquitin specific peptidase 1 Gene

USP1 - ubiquitin specific peptidase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 1

种属: Homo sapiens

同用名: UBP

基因 ID: 7398 | 基因类型: protein coding

关于 USP1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,436,395-62,451,804 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues and 71 paralogues. Broad expression in testis (RPKM 29.9), bone marrow (RPKM 17.7) and 25 other tissues.

功能概要

该基因编码泛素特异性加工 (UBP) 蛋白酶家族的一个成员，该家族是一种具有 His 和 Cys 结构域的去泛素化酶 (DUB) 。该蛋白质位于细胞质中并从泛素融合前体和泛素化蛋白质中切割泛素部分。该蛋白特异性去泛素化范可尼贫血 (FA) DNA 修复途径中的一种蛋白。已经表征了替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating Enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

USP1 基因产物(3)

mRNA Protein Name
NM_001017415.2 NP_001017415.1 ubiquitin carboxyl-terminal hydrolase 1
NM_001017416.2 NP_001017416.1 ubiquitin carboxyl-terminal hydrolase 1
NM_003368.5 NP_003359.3 ubiquitin carboxyl-terminal hydrolase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
18082604 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: 通过突变表型推断
20129063 GOA
enables peptidase activity EXP
EXP: 通过实验结果推断
16531995 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18082604 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in monoubiquitinated protein deubiquitination IMP
IMP: 通过突变表型推断
20129063 GOA
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
37289831 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
18082604 GOA
involved in regulation of DNA repair IDA
IDA: 通过直接分析推断
18082604 GOA
involved in response to UV IDA
IDA: 通过直接分析推断
18082604 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
18082604 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

USP1 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (81 - 600)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (735 - 782)

  • 0
  • 200
  • 400
  • 600
  • 785 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 1

Ubiquitinyl hydrolase 1, Ubiquitin carboxyl-terminal hydrolase 1, ubiquitin thiolesterase 1

USP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
USP1 O94782 WDR48 Homo sapiens Q8TAF3
Anti Tag CoIP
33961781
种属内
USP1 O94782 WDR48 Homo sapiens Q8TAF3
Anti Tag CoIP
28514442
种属内
USP1 O94782 WDR48 Homo sapiens Q8TAF3
Anti Tag CoIP
35271311
种属内
USP1 O94782 WDR48 Homo sapiens Q8TAF3
Anti Tag CoIP
19615732
种属内
USP1 O94782 WDR48 Homo sapiens Q8TAF3-1
Anti Tag CoIP
26388029
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group I

Fanconi Anemia Complementation Group I

FANCI
Mast Syndrome

SPG21

Spastic Paraplegia 21, Autosomal Recessive

Autosomal Recessive Spastic Paraplegia Type 21

Autosomal Recessive Spastic Paraplegia 21

Hereditary Spastic Paraplegia 21
Fanconi Anemia, Complementation Group D2

Fanconi Anemia Complementation Group D2

FANCD2

Fad2

Fa4

Fancd

Fanconi Pancytopenia Type 4

Fanconi Anemia, Complementation Group D

Fanconi Pancytopenia, Type 4

Facd

Fanconi Anemia Complementation Group D
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis

KMIN

Kin

Systemic Karyomegaly

Karyomegalic Tubulointerstitial Nephritis

Ktn
Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145471 KSQ-4279 Inhibitor 99.95% 否
HY-153731 USP1-IN-4 Inhibitor / 否
HY-145471A KSQ-4279 (gentisate) Inhibitor / 否
HY-161878 USP1-IN-10 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus USP1 RGD RGD:1306461
Canis familiaris USP1 VGNC VGNC:48177
Felis catus USP1 VGNC VGNC:66864
Macaca mulatta USP1 VGNC VGNC:78733
Mus musculus USP1 MGD MGI:2385198
Bos taurus USP1 VGNC VGNC:36709
Others USP1 NCBI
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