2. Gene
  3. VEGFB - vascular endothelial growth factor B Gene

VEGFB - vascular endothelial growth factor B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管内皮生长因子 B

种属: Homo sapiens

同用名: VRF; VEGFL

基因 ID: 7423 | 基因类型: protein coding

关于 VEGFB

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,234,584-64,239,264 (from NCBI)

This gene has 4 transcripts (splice variants), 167 orthologues and 4 paralogues. Broad expression in fat (RPKM 106.2), heart (RPKM 26.1) and 23 other tissues.

功能概要

该基因编码 PDGF (血小板衍生生长因子) /VEGF (血管内皮生长因子) 家族的成员。 VEGF 家族成员调节血管的形成并参与内皮细胞生理学。该成员是 VEGFR-1 (血管内皮生长因子受体 1) 和 NRP-1 (neuropilin-1) 的配体。对小鼠的研究表明，该基因与核编码的线粒体基因共表达，编码的蛋白质特异性控制脂肪酸的内皮摄取。已经鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

VEGFB 基因产物(2)

mRNA Protein Name
NM_001243733.2 NP_001230662.1 vascular endothelial growth factor B isoform VEGFB-167 precursor
NM_003377.5 NP_003368.1 vascular endothelial growth factor B isoform VEGFB-186 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chemoattractant activity IDA
IDA: 通过直接分析推断
19275959 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11122379 GOA
enables vascular endothelial growth factor receptor 1 binding IPI
IPI: 通过物理相互作用推断
12366396 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in induction of positive chemotaxis IDA
IDA: 通过直接分析推断
19275959 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
18259607 GOA
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
18259607 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
18259607 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18259607 GOA
involved in positive regulation of endothelial cell proliferation IDA
IDA: 通过直接分析推断
8637916 GOA
involved in positive regulation of mast cell chemotaxis IDA
IDA: 通过直接分析推断
19275959 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11122379 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
18259607 GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
18259607 GOA
NOT involved in positive regulation of vascular permeability IDA
IDA: 通过直接分析推断
16109918 GOA
involved in positive regulation of vascular wound healing IDA
IDA: 通过直接分析推断
16109918 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
8637916 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VEGFB 蛋白结构

PDGF

PDGF: PDGF/VEGF domain (47 - 124)

  • 0
  • 100
  • 207 a.a.
蛋白主名 其他名称

vascular endothelial growth factor B

VEGF-related factor

VEGFB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VEGFB P49765 KLHL12 Homo sapiens Q53G59
Validated Y2H
32296183
种属内
VEGFB P49765 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
种属内
VEGFB P49765 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 VEGFB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72431 VEGF-BB Protein, Human (HEK293, Fc) P49765 (P22-A207) ≥95%

VEGFB 抗体

目录号 产品名 应用 反应物种
HY-P82882 VEGFB Antibody (YA2627) WB Human, Mouse

关联疾病

疾病名称 别名
Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Senile Macular Degeneration

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2
Blood Group, Globoside System

Globe Disease

GLOB

Blood Group System, Globoside
Kuhnt-Junius Degeneration

Neovascular Age-Related Macular Degeneration

Exudative Senile Macular Degeneration Of Retina

Senile Macular Degeneration, Wet

Wet Senile Macular Retinal Degeneration

Exudative Age-Related Macular Degeneration

Exudative Macular Degeneration
Macular Retinal Edema

Macular Edema

Macular Oedema

Macular Retinal Oedema

Macular Edema, Cystoid
Retinal Vascular Occlusion

Retinal Vasc. Occlusion

Occlusion Of Retinal Vessels

Retinal Obstruction
Diabetic Macular Edema
Neovascular Glaucoma

Glaucoma, Neovascular

Secondary Angle-Closure Glaucoma With Rubeosis

Glaucoma Neovascular
Endophthalmitis
Central Retinal Vein Occlusion

Crvo
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Degeneration Of Macula And Posterior Pole

Degeneration Of Macula And Posterior Pole Of Retina

Degeneration Of Macula Or Posterior Pole

Macular Degeneration Nos

Degenerative Disorder Of Macula

Drusen Macular Degeneration

Posterior Pole Macular Degeneration Of Eye

Macular Eye Degeneration

Macular Degeneration Of Retina, Unspecified

Pseudohole Degeneration Of Macula Of Retina
Retinal Perforation

Retinal Break

Retinal Perforations

Retinal Dialysis

Retinal Tear

Retinal Break Nos

Ruptured Retina
Cleidocranial Dysplasia

Cleidocranial Dysostosis

CLCD

Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only

Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly

CCD

Marie-Sainton Disease

Dysplasia Cleidocranial

Dento-Osseous Dysplasia

Marie-Sainton Syndrome

Dysplasia, Cleidocranial
Retinal Artery Occlusion

Retina Artery Narrowing

Retinal Artery Spasm

Spasm Of Ophthalmic Artery

Retinal Spasm

Vasospasm Of Retina
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Malignant Renovascular Hypertension

Secondary Malignant Renovascular Hypertension
Ureteric Orifice Cancer

Malignant Neoplasm Of Ureteric Orifice Of Urinary Bladder

Malignant Tumor Of Ureteric Orifice

Orifice Of The Ureter
Degenerative Myopia

Pathological Myopia

Myopia, Degenerative

Degenerative Progressive High Myopia

Progressive High Myopia

Progressive High Myopia
Familiar Ovarian Carcinoma
Severe Nonproliferative Diabetic Retinopathy

High Risk Non Proliferative Diabetic Retinopathy

Severe Npdr
Background Diabetic Retinopathy

Non Proliferative Diabetic Retinopathy

Non-Proliferative Diabetic Retinopathy

Nonproliferative Diabetic Retinopathy
Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction

Adenocarcinoma Of Gastroesophageal Junction

Adenocarcinoma Of The Gastroesophageal Junction
Retinal Vascular Disease

Retinal Vascular

Retinal Vascular Disorder

Retina Circulation Disorder
Vein Disease

Disorder Of Vein
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity

Retrolental Fibroplasia

EVR1

Criswick-Schepens Syndrome

Rop

Exudative Vitreoretinopathy, Familial, Autosomal Dominant

Fevr, Autosomal Dominant

Premature Retinopathy

Vitreoretinopathy, Exudative 1

Autosomal Dominant Familial Exudative Vitreoretinopathy

Fevr

Vitreoretinopathy, Exudative, Type 1

Retinopathy Of Prematurity Nos

Rlf- [Retrolental Fibroplasia]

Rop - [Retinopathy Of Prematurity]

Terry Syndrome
Malignant Secondary Hypertension
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos
Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P10550 VGB4 Antagonist / 否
HY-P10831 GNQWFI Antagonist / 否
HY-RS15636 VEGFB Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990758 Reflocibart / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta VEGFB VGNC VGNC:78765
Rattus norvegicus VEGFB RGD RGD:619799
Felis catus VEGFB VGNC VGNC:81095
Bos taurus VEGFB VGNC VGNC:97324
Mus musculus VEGFB MGD MGI:106199
Canis familiaris VEGFB VGNC VGNC:48251
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