2. Gene
  3. VGF - VGF nerve growth factor inducible Gene

VGF - VGF nerve growth factor inducible Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：VGF 神经生长因子诱导型

种属: Homo sapiens

同用名: SCG7; SgVII

基因 ID: 7425 | 基因类型: protein coding

关于 VGF

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,162,509-101,169,952 (from NCBI)

This gene has 2 transcripts (splice variants) and 72 orthologues. Biased expression in brain (RPKM 14.2) and fat (RPKM 1.5).

功能概要

该基因在神经内分泌细胞亚群中特异性表达，并被神经生长因子上调。该基因的结构组织与大鼠基因相似，翻译区和非翻译区均显示出与大鼠基因高度的序列相似性。编码的分泌蛋白也与 secretogranin/chromogranin 家族有相似之处，但其确切功能尚不清楚。[RefSeq 提供，2008 年 7 月]

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

VGF 基因产物(1)

mRNA Protein Name
NM_003378.4 NP_003369.2 neurosecretory protein VGF precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to cAMP IEP
IEP: 通过表达模式推断
10381005 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
17440014 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
15706611 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurosecretory protein VGF

neuro-endocrine specific protein VGF

关联疾病

疾病名称 别名
Vaccinia
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes
Spinocerebellar Ataxia 23

Spinocerebellar Ataxia Type 23

SCA23

Ataxia, Spinocerebellar, Type 23
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1345A TLQP-21 TFA Agonist 99.90% 否
HY-107760A Decanoyl-RVKR-CMK TFA Inhibitor 98.04% 否
HY-107760 Decanoyl-RVKR-CMK Inhibitor 98.02% 否
HY-P1345 TLQP-21 Agonist / 否
HY-RS15643 VGF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta VGF VGNC VGNC:78767
Rattus norvegicus VGF RGD RGD:69399
Canis familiaris VGF VGNC VGNC:54090
Felis catus VGF VGNC VGNC:107829
Bos taurus VGF VGNC VGNC:36790
Mus musculus VGF MGD MGI:1343180
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