CORO2A - coronin 2A Gene

中文名称：冠宁 2A

种属: Homo sapiens

同用名: IR10; WDR2; CLIPINB

关于 CORO2A

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 括起来，这可能有助于异源三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、细胞凋亡和基因调控。该蛋白包含 5 个 WD 重复序列，与肌动蛋白结合蛋白 (D. discoideum coronin 和人类 p57 蛋白) 具有结构相似性，表明该蛋白也可能是调节细胞运动的肌动蛋白结合蛋白。该基因的选择性剪接产生 2 个转录本变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]