2. Gene
  3. Ddit4 - DNA-damage-inducible transcript 4 Gene

Ddit4 - DNA-damage-inducible transcript 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: dig2; REDD1; Rtp801; 5830413E08Rik

基因 ID: 74747 | 基因类型: protein coding

关于 Ddit4

功能概要

Enables 14-3-3 protein binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; negative regulation of TOR signaling; and negative regulation of glycolytic process. Located in mitochondrion. Is expressed in reproductive system and retina nuclear layer. Orthologous to human DDIT4 (DNA damage inducible transcript 4). [provided by Alliance of Genome Resources, Apr 2022]

Ddit4 基因产物(1)

mRNA Protein Name
NM_029083.2 NP_083359.1 DNA damage-inducible transcript 4 protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 14-3-3 protein binding IDA
IDA: 通过直接分析推断
18198340 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: 通过直接分析推断
17556672 MGI
involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
21896779 MGI
acts upstream of or within negative regulation of TOR signaling IMP
IMP: 通过突变表型推断
18198340 MGI
acts upstream of or within negative regulation of glycolytic process IMP
IMP: 通过突变表型推断
20176937 MGI
acts upstream of or within protein-containing complex disassembly IMP
IMP: 通过突变表型推断
18198340 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
20176937 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
18198340 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
20176937 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA damage-inducible transcript 4 protein

HIF-1 responsive RTP801

HIF-1 responsive protein RTP801

REDD-1

dexamethasone-induced gene 2 protein

protein regulated in development and DNA damage response 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03615 DDIT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16246 Ddit4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03616 DDIT4L Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16295 Macc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ddit4 NCBI NCBI:54541
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