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  2. XPNPEP1 - X-prolyl aminopeptidase 1 Gene

XPNPEP1 - X-prolyl aminopeptidase 1 Gene

中文名称:X-脯氨酰氨肽酶 1

种属: Homo sapiens

同用名: APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1

基因 ID: 7511 | 基因类型: protein coding

关于 XPNPEP1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:109,864,766-109,923,511 (from NCBI)

This gene has 29 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 32.0), duodenum (RPKM 25.3) and 25 other tissues.

功能概要

该基因编码胞质形式的金属氨肽酶,该酶催化裂解与脯氨酸残基相邻的 N 末端氨基酸。基因产物可能在速激肽、神经肽和肽类激素的降解和成熟中发挥作用。可变剪接导致多个转录变体。[RefSeq 提供,2009 年 11 月]

This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide Hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

XPNPEP1 基因产物(9)

mRNA Protein Name
NM_001167604.2 NP_001161076.1 xaa-Pro aminopeptidase 1 isoform 2
NM_001324128.2 NP_001311057.1 xaa-Pro aminopeptidase 1 isoform 3
NM_001324131.2 NP_001311060.1 xaa-Pro aminopeptidase 1 isoform 4
NM_001324132.2 NP_001311061.1 xaa-Pro aminopeptidase 1 isoform 5
NM_001324133.2 NP_001311062.1 xaa-Pro aminopeptidase 1 isoform 6
NM_001324134.2 NP_001311063.1 xaa-Pro aminopeptidase 1 isoform 7
NM_001324135.2 NP_001311064.1 xaa-Pro aminopeptidase 1 isoform 8
NM_001324136.1 NP_001311065.1 xaa-Pro aminopeptidase 1 isoform 9
NM_020383.4 NP_065116.3 xaa-Pro aminopeptidase 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity IDA
IDA: 通过直接分析推断
11106490 GOA
enables manganese ion binding IDA
IDA: 通过直接分析推断
18515364 GOA
enables metalloaminopeptidase activity IDA
IDA: 通过直接分析推断
18515364 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
18515364 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bradykinin catabolic process IDA
IDA: 通过直接分析推断
18515364 GOA
involved in negative regulation of programmed cell death IDA
IDA: 通过直接分析推断
35165443 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
11106490 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
11106490 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

XPNPEP1 蛋白结构

Creatinase_N

Creatinase_N: Creatinase/Prolidase N-terminal domain (55 - 191)

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (371 - 585)

  • 0
  • 200
  • 400
  • 600
  • 666 a.a.
蛋白主名 其他名称

xaa-Pro aminopeptidase 1

X-Pro aminopeptidase 1

重组 XPNPEP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7498 Aminopeptidase P1 Protein, Human (His) Q9NQW7 (P2-Q622) ≥95%
HY-P700260 Aminopeptidase P1 Protein, Human (His-SUMO) Q9NQW7 (P2-Q623) ≥95%

关联疾病

疾病名称 别名
Biliary Atresia

Congenital Biliary Atresia

Isolated Biliary Atresia

Isolated Atresia Of Bile Ducts

Non-Syndromic Biliary Atresia

Atresia Of Bile Duct

Biliary Atresia, Congenital

Atresia Of Bile Ducts

Bile Duct Atresia

Congenital Bile Duct Atresia

Ba - [Biliary Atresia]

Impervious Bile Duct

Atresia Of Common Duct

Biliary Duct Atresia

Bile Ductal Atresia

Cystic Duct Atresia

Chicken Egg Allergy

Gallus Gallus Egg Allergy

Mature Cataract

Total Or Mature Cataract

Total, Mature Senile Cataract

Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1

CGD1

Ncf1 Deficiency

Soluble Oxidase Component Ii Deficiency

Soc2 Deficiency

P47-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I

Deficiency Of Neutrophil Cytosol Factor 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I

Cgd, Autosomal Recessive Cytochrome B-Positive, Type I

Granulomatous Disease, Chronic, Due To Ncf1 Deficiency

Neutrophil Cytosol Factor 1 Deficiency

Chronic Granulomatous Disease 1, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 1

Cdg1

Deficiency Of Ncf1

Deficiency Of P47-Phox

Deficiency Of Soc2

Deficiency Of Soluble Oxidase Component Ii

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I

Chronic Granulomatous Disease Due To Ncf1 Deficiency

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus XPNPEP1 VGNC VGNC:67110
Rattus norvegicus XPNPEP1 RGD RGD:621274
Canis familiaris XPNPEP1 VGNC VGNC:48457
Macaca mulatta XPNPEP1 VGNC VGNC:78810
Mus musculus XPNPEP1 MGD MGI:2180003
Bos taurus XPNPEP1 VGNC VGNC:36994
Others XPNPEP1 NCBI