XRCC2 - X-ray repair cross complementing 2 Gene

中文名称：X 光修复交叉补 2

种属: Homo sapiens

同用名: FANCU; POF17; SPGF50

基因 ID: 7516 | 基因类型: protein coding

关于 XRCC2

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:152,644,776-152,676,141 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues, 6 paralogues and is associated with 6 phenotypes. Broad expression in testis (RPKM 1.4), bone marrow (RPKM 1.0) and 22 other tissues.

功能概要

该基因编码 RecA/RAD51 相关蛋白家族的一个成员，参与同源重组以维持染色体稳定性和修复 DNA 损伤。该基因参与通过同源重组修复 DNA 双链断裂，并在功能上补充中国仓鼠 irs1，后者是一种修复缺陷型突变体，对多种不同的 DNA 损伤剂表现出超敏反应。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]

XRCC2 基因产物(1)

mRNA	Protein	Name
NM_005431.2	NP_005422.1	DNA repair protein XRCC2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to four-way junction DNA binding	IDA IDA: 通过直接分析推断	20207730	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10749867	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA repair	IGI IGI: 通过遗传相互作用推断	10422536	GOA
involved in DNA strand invasion	IDA IDA: 通过直接分析推断	11834724	GOA
involved in centrosome cycle	IMP IMP: 通过突变表型推断	21276791	GOA
involved in double-strand break repair via homologous recombination	IMP IMP: 通过突变表型推断	23149936	GOA
involved in mitotic cell cycle	IMP IMP: 通过突变表型推断	21276791	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Rad51B-Rad51C-Rad51D-XRCC2 complex	IDA IDA: 通过直接分析推断	11751635	GOA
located in centrosome	IDA IDA: 通过直接分析推断	21276791	GOA
located in replication fork	IDA IDA: 通过直接分析推断	20207730	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XRCC2 蛋白结构

Rad51

0
100
200
280 a.a.

蛋白主名

其他名称

DNA repair protein XRCC2

X-ray repair complementing defective repair in Chinese hamster cells 2

XRCC2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	28514442
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Bait CoIP	11842113
Intra	XRCC2	O43543	RAD51C	Homo sapiens	O43502	Anti Tag CoIP	33961781
Intra	XRCC2	O43543	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	XRCC2	O43543	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Premature Ovarian Failure 17

POF17

Ovarian Failure, Premature, Type 17

Spermatogenic Failure 50

SPGF50

Fanconi Anemia, Complementation Group U

Fanconi Anemia Complementation Group U

FANCU

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome	Common Syndrome
Bap1 Cancer Syndrome	Bap1-Tpds
Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms	Tumor Predisposition Syndrome
Tumor Susceptibility Linked To Germline Bap1 Mutations	Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms
Tumor Predisposition

Short Stature, Microcephaly, And Endocrine Dysfunction

SSMED

Hereditary Breast Cancer

Familial Breast Cancer	Familial Breast Carcinoma
Hereditary Breast Carcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Cervix Melanoma

Infertility

Lipodystrophy, Familial Partial, Type 6

FPLD6	Lipe-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 6	Lipe-Related Fpld
Lipodystrophy, Familial Partial, Associated With Lipe Mutations	Familial Partial Lipodystrophy Associated With Lipe Mutations
Lipodystrophy, Familial Partial, 6

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15897	XRCC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	XRCC2	VGNC	VGNC:48466
Mus musculus	XRCC2	MGD	MGI:1927345
Felis catus	XRCC2	VGNC	VGNC:67117
Macaca mulatta	XRCC2	VGNC	VGNC:78813
Bos taurus	XRCC2	VGNC	VGNC:37003
Rattus norvegicus	XRCC2	RGD	RGD:1564823

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

XRCC2 - X-ray repair cross complementing 2 Gene

关于 XRCC2

功能概要

XRCC2 基因产物(1)

XRCC2 蛋白结构

XRCC2 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

XRCC2 - X-ray repair cross complementing 2 Gene

关于 XRCC2

功能概要

XRCC2 基因产物(1)

XRCC2 蛋白结构

XRCC2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z