ZFX - zinc finger protein X-linked Gene

中文名称：X 连锁锌指蛋白

种属: Homo sapiens

同用名: ZNF926

关于 ZFX

功能概要

染色体上的这个基因在结构上与 Y 染色体上的相关基因相似。它编码 krueppel C2H2 型锌指蛋白家族的一个成员。全长蛋白包含一个酸性转录激活结构域 (AD) 、一个核定位序列 (NLS) 和一个由 13 个 C2H2 型锌指组成的 DNA 结合结构域 (DBD) 。对小鼠胚胎和成体造血干细胞的研究表明，该基因是两种干细胞类型自我更新所必需的转录调节因子，但对于它们后代的生长和分化来说是可有可无的。已经鉴定出编码不同同种型的多个可变剪接转录物变体，但尚未确定某些变体的全长性质。[RefSeq 提供，2010 年 5 月]

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]