2. Gene
  3. ZNF2 - zinc finger protein 2 Gene

ZNF2 - zinc finger protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指蛋白 2

种属: Homo sapiens

同用名: A1-5; ZNF661; Zfp661

基因 ID: 7549 | 基因类型: protein coding

关于 ZNF2

Cytogenetic location: 2q11.1 Genomic coordinates (GRCh38): 2:95,165,809-95,184,317 (from NCBI)

This gene has 5 transcripts (splice variants), 95 orthologues and 174 paralogues. Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 C2H2 型锌指蛋白家族。该基因的确切功能尚不清楚，但已知锌指蛋白与 DNA 相互作用并作为转录调节因子发挥作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 4 月]

The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

ZNF2 基因产物(5)

mRNA Protein Name
NM_001017396.3 NP_001017396.1 zinc finger protein 2 isoform b
NM_001282398.2 NP_001269327.1 zinc finger protein 2 isoform c
NM_001291604.2 NP_001278533.1 zinc finger protein 2 isoform d
NM_001291605.2 NP_001278534.1 zinc finger protein 2 isoform e
NM_021088.4 NP_066574.2 zinc finger protein 2 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF2 蛋白结构

KRAB

KRAB: KRAB box (14 - 54)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (188 - 213)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (216 - 239)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (244 - 267)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (272 - 296)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (301 - 324)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (356 - 380)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (385 - 409)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
蛋白主名 其他名称

zinc finger protein 2

zinc finger protein 2.2

ZNF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZNF2 Q9BSG1 TRIM41 Homo sapiens Q8WV44
Y2H Array
32296183
种属内
ZNF2 Q9BSG1 TRIM41 Homo sapiens Q8WV44
Y2H Prey Pooling
32296183
种属内
ZNF2 Q9BSG1 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
种属内
ZNF2 Q9BSG1 DVL3 Homo sapiens Q92997
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Holoprosencephaly 5

HPE5

Holoprosencephaly-5

Holoprosencephaly, Type 5
Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3

FHL3

Hplh3

Hlh3

Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis
Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal
Cryptococcosis

Cryptococcus Neoformans Infection

Torulosis

Busse-Buschke'S Disease

Cryptococcal Infection

European Cryptococcosis

Torula

Infection By Cryptococcus Neoformans

Cryptococcosis Infection

European Blastomycosis

European Blastomycotic Infection

European Blastomycoses Infection

Torula Histolytica Infection
Hemophagocytic Lymphohistiocytosis, Familial, 1

Familial Hemophagocytic Lymphohistiocytosis

Fhl

Familial Erythrophagocytic Lymphohistiocytosis

Hemophagocytic Syndrome

FHL1

Hplh1

Hlh1

Fel

Familial Hemophagocytic Lymphohistiocytosis 1

Primary Hemophagocytic Lymphohistiocytosis

Familial Hlh

Hlh

Familial Hemophagocytic Lymphocytosis

Hemophagocytic Lymphohistiocytosis, Familial

Reticulosis, Familial Histiocytic

Hemophagocytic Reticulosis, Familial

Erythrophagocytic Lymphohistiocytosis, Familial

Familial Histiocytic Reticulosis

Familial Hemophagocytic Histiocytosis

Familial Hemophagocytic Reticulosis

Fhlh

Hplh

Primary Hemophagocytic Hymphohistiocytosis

Genetic Hemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis

Familial Hemophagocytic Lymphohistiocytosis Type 1
Potocki-Lupski Syndrome

PTLS

Chromosome 17p11.2 Duplication Syndrome

17p11.2 Microduplication Syndrome

Duplication 17p11.2 Syndrome

Trisomy 17p11.2

Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

17p11.2 Duplication Syndrome

Dup(17)(P11.2p11.2)

Pls

Chromosome 17, Trisomy 17p11 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16108 ZNF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZNF2 RGD RGD:6500748
Macaca mulatta ZNF2 VGNC VGNC:106247
Bos taurus ZNF2 VGNC VGNC:37221
Mus musculus ZNF2 MGD MGI:1919430
Others ZNF2 NCBI
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