2. Gene
  3. PTP4A1 - protein tyrosine phosphatase 4A1 Gene

PTP4A1 - protein tyrosine phosphatase 4A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酪氨酸磷酸酶 4A1

种属: Homo sapiens

同用名: HH72; PRL1; PRL-1; PTPCAAX1; PTP(CAAX1)

基因 ID: 7803 | 基因类型: protein coding

关于 PTP4A1

Cytogenetic location: 6q12 Genomic coordinates (GRCh38): 6:63,516,440-63,583,588 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 8 paralogues. Broad expression in liver (RPKM 141.5), adrenal (RPKM 72.5) and 24 other tissues.

功能概要

该基因编码一小类异戊二烯化蛋白酪氨酸磷酸酶 (PTP) 的成员，其中包含一个 PTP 结构域和一个特征性的 C 末端异戊二烯化基序。编码的蛋白质是一种细胞信号分子，在各种细胞过程中发挥调节作用，包括细胞增殖和迁移。该蛋白质还可能参与癌症的发展和转移。这种酪氨酸磷酸酶是一种核蛋白，但可能通过其异戊二烯化基序与质膜结合。与该基因相关的假基因位于染色体 1、2、5、7、11 和 X。[RefSeq 提供，2013 年 6 月]

This gene encodes a member of a small class of prenylated Protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in Cancer development and metastasis. This tyrosine Phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

PTP4A1 基因产物(14)

mRNA Protein Name
NM_001385254.1 NP_001372183.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385255.1 NP_001372184.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385256.1 NP_001372185.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385257.1 NP_001372186.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385258.1 NP_001372187.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385259.1 NP_001372188.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385260.1 NP_001372189.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385262.2 NP_001372191.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385263.2 NP_001372192.1 protein tyrosine phosphatase type IVA 1 isoform 2
NM_001385265.1 NP_001372194.1 protein tyrosine phosphatase type IVA 1 isoform 3
NM_001385266.1 NP_001372195.1 protein tyrosine phosphatase type IVA 1 isoform 4
NM_001385267.2 NP_001372196.1 protein tyrosine phosphatase type IVA 1 isoform 1
NM_001385268.2 NP_001372197.1 protein tyrosine phosphatase type IVA 1 isoform 5
NM_003463.5 NP_003454.1 protein tyrosine phosphatase type IVA 1 isoform 1

PTP4A1 蛋白结构

DSPc

DSPc: Dual specificity phosphatase, catalytic domain (34 - 142)

  • 0
  • 100
  • 173 a.a.
蛋白主名 其他名称

protein tyrosine phosphatase type IVA 1

PVT1/PTP4A1 fusion

重组 PTP4A1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P701032 PTP4A1 Protein, Human (His) Q93096 (M1-C170) ≥95%

关联疾病

疾病名称 别名
Ovarian Lymphoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135457 JMS-053 ≥98.0% 否
HY-RS11409 PTP4A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTP4A1 VGNC VGNC:33523
Mus musculus PTP4A1 MGD MGI:1277096
Macaca mulatta PTP4A1 VGNC VGNC:83452
Felis catus PTP4A1 VGNC VGNC:97575
Rattus norvegicus PTP4A1 RGD RGD:61970
Others PTP4A1 NCBI
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