MANF - mesencephalic astrocyte derived neurotrophic factor Gene

中文名称：中脑星形胶质细胞源性神经营养因子

种属: Homo sapiens

同用名: ARP; ARMET

关于 MANF

功能概要

由该基因编码的蛋白质位于内质网 (ER) 和高尔基体中，并且也被分泌。减少该基因的表达会增加对 ER 应激诱导的死亡的易感性并导致细胞增殖。这种蛋白质的活性对于促进多巴胺能神经元的存活很重要。在多种实体瘤中已报道 N 末端富含精氨酸的区域存在多态性，包括将 ATG 起始密码子更改为 AGG 的特定突变；然而，这些多态性后来被证明存在于正常组织中，因此不再被认为与肿瘤相关。[RefSeq 提供，2014 年 4 月]

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]