Scn9a - sodium voltage-gated channel alpha subunit 9 Gene

中文名称：钠电压门控通道 α 亚基 9

种属: Rattus norvegicus

同用名: PN1; Scn2a; Nav1.7

关于 Scn9a

功能概要

该基因编码的蛋白可启动钠离子结合活性和电压门控钠通道活性。涉及多个过程，包括对福尔马林引起的疼痛的行为反应；动作电位的负调节；和神经元动作电位。位于轴突。电压门控钠通道复合体的一部分。该基因的人类直系同源物与红斑性肢痛有关；全身性癫痫伴热性惊厥加 7；和阵发性极度疼痛障碍。与人类 SCN9A（钠电压门控通道 α 亚基 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables sodium ion binding activity and voltage-gated Sodium Channel activity. Involved in several processes, including behavioral response to formalin induced pain; negative regulation of action potential; and neuronal action potential. Located in axon. Part of voltage-gated Sodium Channel complex. Human ortholog(s) of this gene implicated in erythromelalgia; generalized epilepsy with febrile seizures plus 7; and paroxysmal extreme pain disorder. Orthologous to human SCN9A (sodium voltage-gated channel alpha subunit 9). [provided by Alliance of Genome Resources, Apr 2022]