CENPM - centromere protein M Gene

中文名称：着丝粒蛋白 M

种属: Homo sapiens

同用名: PANE1; CENP-M; C22orf18

关于 CENPM

功能概要

由该基因编码的蛋白质是着丝粒的内部蛋白质，着丝粒是结合纺锤体微管以调节细胞分裂过程中染色体分离的多蛋白复合物。它属于构成性着丝粒相关网络蛋白组，其成员与外部着丝粒蛋白相互作用，并有助于在每个细胞分裂周期中维持着丝粒特性。该蛋白质在结构上与 GTP 酶相关，但不能结合三磷酸鸟苷。影响与另一种组成性着丝粒相关网络蛋白 CENP-I 相互作用的点突变会损害着丝粒组装和染色体排列，表明它是着丝粒形成所必需的。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 1 月]

The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]