AHNAK - AHNAK nucleoprotein Gene

中文名称：AHNAK 核蛋白

种属: Homo sapiens

同用名: PM227; AHNAK1; AHNAKRS

关于 AHNAK

功能概要

由该基因编码的蛋白质是一种大型 (700 kDa) 结构支架蛋白，由具有 128 个氨基酸重复的中央结构域组成。编码的蛋白质可能在血脑屏障形成、细胞结构和迁移、心脏钙通道调节和肿瘤转移等多种过程中发挥作用。该基因存在编码 17 kDa 同种型的更短变体，并且更短的同种型启动调节该基因可变剪接的反馈回路。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac Calcium Channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016]