2. Gene
  3. FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

FTO - FTO alpha-ketoglutarate dependent dioxygenase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：FTO α-酮戊二酸依赖性双加氧酶

种属: Homo sapiens

同用名: GDFD; ALKBH9; BMIQ14

基因 ID: 79068 | 基因类型: protein coding

关于 FTO

Cytogenetic location: 16q12.2 Genomic coordinates (GRCh38): 16:53,703,963-54,121,941 (from NCBI)

This gene has 23 transcripts (splice variants), 202 orthologues and is associated with 4 phenotypes. Ubiquitous expression in brain (RPKM 7.3), adrenal (RPKM 4.2) and 25 other tissues.

功能概要

该基因是与 AlkB 相关的非血红素铁和 2-酮戊二酸依赖性加氧酶超家族的核蛋白，但该基因的确切生理功能尚不清楚。其他非血红素铁酶可通过氧化去甲基作用逆转烷基化 DNA 和 RNA 损伤。对小鼠和人类的研究表明，它在神经和心血管系统中发挥作用，并且与体重指数、肥胖风险和 2 型糖尿病密切相关。[RefSeq 提供，2011 年 7 月]

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron Enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

FTO 基因产物(25)

mRNA Protein Name
XM_011523316.4 XP_011521618.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X6
NM_001363896.1 NP_001350825.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 4
NM_001363905.1 NP_001350834.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 11
XR_007064911.1
NR_156761.1
NM_001363894.1 NP_001350823.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 1
XM_017023654.3 XP_016879143.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X1
XM_047434607.1 XP_047290563.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X3
NM_001363898.1 NP_001350827.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 6
NM_001080432.3 NP_001073901.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 3
NM_001363900.1 NP_001350829.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 8
XM_011523315.4 XP_011521617.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X5
XM_017023656.3 XP_016879145.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X7
NM_001363901.1 NP_001350830.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 9
XM_047434606.1 XP_047290562.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X2
XM_047434609.1 XP_047290565.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
NM_001363891.1 NP_001350820.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 2
XM_011523314.4 XP_011521616.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X4
XM_024450437.2 XP_024306205.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X9
NM_001363903.1 NP_001350832.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 10
NM_001363988.1 NP_001350917.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 12
NM_001363897.1 NP_001350826.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 5
NM_001363899.1 NP_001350828.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform 7
XM_017023657.3 XP_016879146.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X8
XM_047434608.1 XP_047290564.1 alpha-ketoglutarate-dependent dioxygenase FTO isoform X5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables broad specificity oxidative DNA demethylase activity IDA
IDA: 通过直接分析推断
18775698 GOA
enables ferrous iron binding IDA
IDA: 通过直接分析推断
20376003 GOA
enables mRNA N6-methyladenosine dioxygenase activity IDA
IDA: 通过直接分析推断
25452335 GOA
enables mRNA N6-methyladenosine dioxygenase activity IMP
IMP: 通过突变表型推断
26458103 GOA
enables oxidative RNA demethylase activity IDA
IDA: 通过直接分析推断
18775698 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables tRNA demethylase activity IDA
IDA: 通过直接分析推断
30197295 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA alkylation repair IDA
IDA: 通过直接分析推断
18775698 GOA
involved in RNA repair IDA
IDA: 通过直接分析推断
18775698 GOA
involved in mRNA destabilization IDA
IDA: 通过直接分析推断
28002401 GOA
involved in regulation of brown fat cell differentiation IMP
IMP: 通过突变表型推断
26287746 GOA
involved in regulation of lipid storage IMP
IMP: 通过突变表型推断
26287746 GOA
involved in snRNA processing IDA
IDA: 通过直接分析推断
30197295 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28002401 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
22002720 GOA
located in nucleus IDA
IDA: 通过直接分析推断
26458103 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FTO 蛋白结构

FTO_NTD

FTO_NTD: FTO catalytic domain (35 - 326)

FTO_CTD

FTO_CTD: FTO C-terminal domain (329 - 499)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

alpha-ketoglutarate-dependent dioxygenase FTO

AlkB homolog 9

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

fat mass and obesity associated

fat mass and obesity-associated protein

m6A(m)-demethylase FTO

mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

mRNA N(6)-methyladenosine demethylase FTO

tRNA N1-methyl adenine demethylase FTO

FTO 抗体

目录号 产品名 应用 反应物种
HY-P80680 FTO Antibody WB, IHC-P Human

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Growth Retardation, Developmental Delay, And Facial Dysmorphism

Lethal Polymalformative Syndrome, Boissel Type

Growth Retardation, Developmental Delay, Coarse Facies, And Early Death

GDFD

Growth Retardation, Developmental Delay, Facial Dysmorphism

Growth Retardation Developmental Delay Coarse Facies Early Death

Lethal Polymalformative Syndrome Boissel Type
Acquired Metabolic Disease
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Body Mass Index Quantitative Trait Locus 14

Obesity

BMIQ14

Obesity, Susceptibility To

Obesity, Susceptibility To, Bmiq14

Obesity Bmiq14

{Obesity, Susceptibility To, Bmiq14}
Eating Disorder

Eating Disorders

Feeding And Eating Disorders
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Overnutrition
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Diabetes Mellitus

Diabetes
Glucose Intolerance

Glucose: Intolerance

Glucose: Malabsorption

Malabsorption Of Glucose

Impaired Glucose Tolerance
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Cervix Carcinoma

Cancer Of Cervix

Carcinoma Of Cervix

Carcinoma Cervix Uteri

Carcinoma Of The Cervix Uteri
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Leukemia, Myeloid, Acute

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leptin Deficiency Or Dysfunction

Morbid Obesity

Obesity Due To Congenital Leptin Deficiency

LEPD

Congenital Leptin Deficiency

Obesity, Morbid

Obesity, Morbid, Due To Leptin Deficiency

Severe Obesity

Obesity, Morbid, Nonsyndromic 1

Leptin Deficiency

Obesity, Severe, Due To Leptin Deficiency

Morbid Obesity Due To Leptin Deficiency

Obesity Morbid

Leptin Dysfunction

Leptin
Adult Spinal Cord Glioblastoma Multiforme

Glioblastoma Multiforme Of Spinal Cord

Adult Spinal Cord Glioblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14280 Entacapone Inhibitor 99.97% 是
HY-B1320 Meclofenamic acid sodium Inhibitor 99.86% 否
HY-117275 Meclofenamic acid Inhibitor 98.60% 否
HY-117275A Meclofenamic acid sodium hydrate Inhibitor / 否
HY-14280R Entacapone (Standard) Inhibitor / 否
HY-14280A Entacapone sodium salt Inhibitor / 否
Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-127103 FB23-2 Inducer 99.93% 否
HY-137187 FB23 98.66% 否
HY-N6769 Radicicol Inhibitor 99.63% 否
HY-101082 N6,2′-O-Dimethyladenosine Inhibitor 99.93% 否
HY-151106 FTO-IN-8 Inhibitor 98.03% 否
HY-149334 ZLD115 Inhibitor 99.24% 否
HY-145238 FTO-IN-6 98.94% 否
HY-138843A FTO-IN-1 TFA 98.06% 否
HY-147011 FTO-IN-7 Inhibitor 99.22% 否
HY-132865 FTO-IN-3 99.79% 否
HY-RS05137 Fto Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W588293 3-Methylthymidine 99.68% 否
HY-117426 MO-I-500 Inhibitor 99.10% 否
HY-14280S Entacapone-d10 Inhibitor ≥98.0% 否
HY-RS05136 FTO Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117275S Meclofenamic acid-d4 Inhibitor / 否
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / 否
HY-132863 FTO-IN-2 / 否
HY-138843 FTO-IN-1 / 否
HY-139820 FTO-IN-4 / 否
HY-139821 FTO-IN-5 / 否
HY-156405 FTO-IN-10 / 否
HY-N10340 Clausine E Inhibitor / 否
HY-RS05138 Fto Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W026109 FTO-IN-12 Inhibitor / 否
HY-131871 Ethyl LipotF Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FTO VGNC VGNC:29138
Canis familiaris FTO VGNC VGNC:41003
Rattus norvegicus FTO RGD RGD:1305121
Felis catus FTO VGNC VGNC:62384
Macaca mulatta FTO VGNC VGNC:72772
Mus musculus FTO MGD MGI:1347093
Others FTO NCBI
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